Increased fasting glucose and the prevalence of arterial stiffness

A cross-sectional study in Chinese adults

Jing Wang, Liping Liu, Yong Zhou, Chunxue Wang, Haitao Hu, Kolin Hoff, Yuming Guo, Xiang Gao, Anxin Wang, Shouling Wu, Xingquan Zhao

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Previous studies have shown that diabetes increases the prevalence of arterial stiffness. However, it remains controversial whether impaired fasting glucose (IFG), a key pre-diabetes condition, is associated with increased risk of arterial stiffness. This study aimed to investigate the relationship between increased fasting plasma glucose (FPG) and the prevalence of arterial stiffness in a Chinese adult population. Methods: A random sample of 5039 participants aged 40 years or older (40.0% female) were enrolled in this study. Information on potential risk factors for cardiovascular disease was collected, and the presence of arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Participants were stratified into three groups: normal fasting glucose (NFG), IFG, and diabetes mellitus (DM). The IFG group was further stratified by quartiles based on the level of FPG into Q1, Q2, Q3, and Q4. Results: Fasting plasma glucose level was found to be independently and positively associated with baPWV. The adjusted odds ratios (ORs) (95% confidence interval (CI)) for arterial stiffness were 1.09 (0.80-1.48), 1.33 (0.98-1.81), 1.27 (0.93-1.73), 1.82 (1.31-2.53), and 2.15 (1.66-2.79) for those in IFG Q1, Q2, Q3, Q4, and DM groups compared with NFG group (P < 0.001), respectively, after adjusting for age, sex, and other potential confounders. Moreover, male participants and participants younger than 60 years were closely associated with the presence and severity of arterial stiffness (P < 0.001). Conclusion: Our study reports a previously unidentified positive association between increased FPG and the prevalence of arterial stiffness, suggesting the importance of FPG control in the prevention of arterial stiffness.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalNeurological Research
Volume36
Issue number5
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Vascular Stiffness
Fasting
Cross-Sectional Studies
Glucose
Pulse Wave Analysis
Ankle
Diabetes Mellitus
Arm
Cardiovascular Diseases
Odds Ratio
Confidence Intervals

Keywords

  • Epidemiology
  • Impaired fasting glucose
  • Prevention
  • Pulse wave velocity
  • Rterial stiffness

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Increased fasting glucose and the prevalence of arterial stiffness : A cross-sectional study in Chinese adults. / Wang, Jing; Liu, Liping; Zhou, Yong; Wang, Chunxue; Hu, Haitao; Hoff, Kolin; Guo, Yuming; Gao, Xiang; Wang, Anxin; Wu, Shouling; Zhao, Xingquan.

In: Neurological Research, Vol. 36, No. 5, 2014, p. 427-433.

Research output: Contribution to journalArticle

Wang, J, Liu, L, Zhou, Y, Wang, C, Hu, H, Hoff, K, Guo, Y, Gao, X, Wang, A, Wu, S & Zhao, X 2014, 'Increased fasting glucose and the prevalence of arterial stiffness: A cross-sectional study in Chinese adults', Neurological Research, vol. 36, no. 5, pp. 427-433. https://doi.org/10.1179/1743132814Y.0000000345
Wang, Jing ; Liu, Liping ; Zhou, Yong ; Wang, Chunxue ; Hu, Haitao ; Hoff, Kolin ; Guo, Yuming ; Gao, Xiang ; Wang, Anxin ; Wu, Shouling ; Zhao, Xingquan. / Increased fasting glucose and the prevalence of arterial stiffness : A cross-sectional study in Chinese adults. In: Neurological Research. 2014 ; Vol. 36, No. 5. pp. 427-433.
@article{279a757fe1ef46509bf8815aaeafdf51,
title = "Increased fasting glucose and the prevalence of arterial stiffness: A cross-sectional study in Chinese adults",
abstract = "Objective: Previous studies have shown that diabetes increases the prevalence of arterial stiffness. However, it remains controversial whether impaired fasting glucose (IFG), a key pre-diabetes condition, is associated with increased risk of arterial stiffness. This study aimed to investigate the relationship between increased fasting plasma glucose (FPG) and the prevalence of arterial stiffness in a Chinese adult population. Methods: A random sample of 5039 participants aged 40 years or older (40.0{\%} female) were enrolled in this study. Information on potential risk factors for cardiovascular disease was collected, and the presence of arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Participants were stratified into three groups: normal fasting glucose (NFG), IFG, and diabetes mellitus (DM). The IFG group was further stratified by quartiles based on the level of FPG into Q1, Q2, Q3, and Q4. Results: Fasting plasma glucose level was found to be independently and positively associated with baPWV. The adjusted odds ratios (ORs) (95{\%} confidence interval (CI)) for arterial stiffness were 1.09 (0.80-1.48), 1.33 (0.98-1.81), 1.27 (0.93-1.73), 1.82 (1.31-2.53), and 2.15 (1.66-2.79) for those in IFG Q1, Q2, Q3, Q4, and DM groups compared with NFG group (P < 0.001), respectively, after adjusting for age, sex, and other potential confounders. Moreover, male participants and participants younger than 60 years were closely associated with the presence and severity of arterial stiffness (P < 0.001). Conclusion: Our study reports a previously unidentified positive association between increased FPG and the prevalence of arterial stiffness, suggesting the importance of FPG control in the prevention of arterial stiffness.",
keywords = "Epidemiology, Impaired fasting glucose, Prevention, Pulse wave velocity, Rterial stiffness",
author = "Jing Wang and Liping Liu and Yong Zhou and Chunxue Wang and Haitao Hu and Kolin Hoff and Yuming Guo and Xiang Gao and Anxin Wang and Shouling Wu and Xingquan Zhao",
year = "2014",
doi = "10.1179/1743132814Y.0000000345",
language = "English (US)",
volume = "36",
pages = "427--433",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "5",

}

TY - JOUR

T1 - Increased fasting glucose and the prevalence of arterial stiffness

T2 - A cross-sectional study in Chinese adults

AU - Wang, Jing

AU - Liu, Liping

AU - Zhou, Yong

AU - Wang, Chunxue

AU - Hu, Haitao

AU - Hoff, Kolin

AU - Guo, Yuming

AU - Gao, Xiang

AU - Wang, Anxin

AU - Wu, Shouling

AU - Zhao, Xingquan

PY - 2014

Y1 - 2014

N2 - Objective: Previous studies have shown that diabetes increases the prevalence of arterial stiffness. However, it remains controversial whether impaired fasting glucose (IFG), a key pre-diabetes condition, is associated with increased risk of arterial stiffness. This study aimed to investigate the relationship between increased fasting plasma glucose (FPG) and the prevalence of arterial stiffness in a Chinese adult population. Methods: A random sample of 5039 participants aged 40 years or older (40.0% female) were enrolled in this study. Information on potential risk factors for cardiovascular disease was collected, and the presence of arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Participants were stratified into three groups: normal fasting glucose (NFG), IFG, and diabetes mellitus (DM). The IFG group was further stratified by quartiles based on the level of FPG into Q1, Q2, Q3, and Q4. Results: Fasting plasma glucose level was found to be independently and positively associated with baPWV. The adjusted odds ratios (ORs) (95% confidence interval (CI)) for arterial stiffness were 1.09 (0.80-1.48), 1.33 (0.98-1.81), 1.27 (0.93-1.73), 1.82 (1.31-2.53), and 2.15 (1.66-2.79) for those in IFG Q1, Q2, Q3, Q4, and DM groups compared with NFG group (P < 0.001), respectively, after adjusting for age, sex, and other potential confounders. Moreover, male participants and participants younger than 60 years were closely associated with the presence and severity of arterial stiffness (P < 0.001). Conclusion: Our study reports a previously unidentified positive association between increased FPG and the prevalence of arterial stiffness, suggesting the importance of FPG control in the prevention of arterial stiffness.

AB - Objective: Previous studies have shown that diabetes increases the prevalence of arterial stiffness. However, it remains controversial whether impaired fasting glucose (IFG), a key pre-diabetes condition, is associated with increased risk of arterial stiffness. This study aimed to investigate the relationship between increased fasting plasma glucose (FPG) and the prevalence of arterial stiffness in a Chinese adult population. Methods: A random sample of 5039 participants aged 40 years or older (40.0% female) were enrolled in this study. Information on potential risk factors for cardiovascular disease was collected, and the presence of arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Participants were stratified into three groups: normal fasting glucose (NFG), IFG, and diabetes mellitus (DM). The IFG group was further stratified by quartiles based on the level of FPG into Q1, Q2, Q3, and Q4. Results: Fasting plasma glucose level was found to be independently and positively associated with baPWV. The adjusted odds ratios (ORs) (95% confidence interval (CI)) for arterial stiffness were 1.09 (0.80-1.48), 1.33 (0.98-1.81), 1.27 (0.93-1.73), 1.82 (1.31-2.53), and 2.15 (1.66-2.79) for those in IFG Q1, Q2, Q3, Q4, and DM groups compared with NFG group (P < 0.001), respectively, after adjusting for age, sex, and other potential confounders. Moreover, male participants and participants younger than 60 years were closely associated with the presence and severity of arterial stiffness (P < 0.001). Conclusion: Our study reports a previously unidentified positive association between increased FPG and the prevalence of arterial stiffness, suggesting the importance of FPG control in the prevention of arterial stiffness.

KW - Epidemiology

KW - Impaired fasting glucose

KW - Prevention

KW - Pulse wave velocity

KW - Rterial stiffness

UR - http://www.scopus.com/inward/record.url?scp=84898757191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898757191&partnerID=8YFLogxK

U2 - 10.1179/1743132814Y.0000000345

DO - 10.1179/1743132814Y.0000000345

M3 - Article

VL - 36

SP - 427

EP - 433

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 5

ER -