Increased Ia-Antigen-Bearing T Cells in Type I Diabetes Mellitus

James S. Goodwin, Richard A. Jackson, Mary Ann Morris, Barton F. Haynes, George S. Eisenbarth

Research output: Contribution to journalLetterpeer-review

6 Scopus citations


To the Editor: Jackson et al., in the April 1 issue, reported an increased percentage of circulating Ia-positive T cells in patients with insulin-requiring diabetes mellitus, as compared with normal controls and with patients with adult-onset diabetes mellitus who were not using insulin.1 They have used this finding to suggest an immunologic basis for Type I diabetes mellitus. I believe that there is a more straightforward explanation for the phenomenon noted. Ia-positive T cells will increase in the circulation dramatically after even minor immunologic perturbations. For example, Yu et al. have reported that the percentage of peripheral-blood Ia-positive T cells.

Original languageEnglish (US)
Pages (from-to)557
Number of pages1
JournalNew England Journal of Medicine
Issue number9
StatePublished - Aug 26 1982
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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