TY - JOUR
T1 - Increased levels of sequence-specific DNA-binding proteins in human cytomegalovirus-infected cells
AU - Boldogh, I.
AU - Fons, M. P.
AU - Albrecht, T.
PY - 1993/12/30
Y1 - 1993/12/30
N2 - Increased levels of active sequence-specific DNA-binding proteins, AP-1, CRE/B, and NFκB were observed in nuclear lysates of human cytomegalovirus-infected cells from 15 min postinfection. The activation of these cellular factors did not require infectious virus or de novo viral protein synthesis, but their abundance was significantly reduced by inhibitors of protein kinase C and/or A. These data suggest that formation of these transcription factors resulted from the virus-cell membrane interaction and/or through the action of virion structural proteins on cytoplasmic forms of these cellular factors.
AB - Increased levels of active sequence-specific DNA-binding proteins, AP-1, CRE/B, and NFκB were observed in nuclear lysates of human cytomegalovirus-infected cells from 15 min postinfection. The activation of these cellular factors did not require infectious virus or de novo viral protein synthesis, but their abundance was significantly reduced by inhibitors of protein kinase C and/or A. These data suggest that formation of these transcription factors resulted from the virus-cell membrane interaction and/or through the action of virion structural proteins on cytoplasmic forms of these cellular factors.
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U2 - 10.1006/bbrc.1993.2647
DO - 10.1006/bbrc.1993.2647
M3 - Article
C2 - 8280168
AN - SCOPUS:0027715461
SN - 0006-291X
VL - 197
SP - 1505
EP - 1510
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -