Abstract
Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controlswomen (NC). Design: We measured plasma melatonin every 30 min from 1800-1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings). Setting: The study was conducted at a university hospital. Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated. Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood. Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores. Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 54-60 |
| Number of pages | 7 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 93 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Increased melatonin and delayed offset in menopausal depression : Role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. / Parry, Barbara L.; Meliska, Charles J.; Sorenson, Diane L.; López, Ana M.; Martínez, Luis F.; Nowakowski, Sara; Hauger, Richard L.; Elliott, Jeffrey A.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 1, 01.2008, p. 54-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased melatonin and delayed offset in menopausal depression
T2 - Role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index
AU - Parry, Barbara L.
AU - Meliska, Charles J.
AU - Sorenson, Diane L.
AU - López, Ana M.
AU - Martínez, Luis F.
AU - Nowakowski, Sara
AU - Hauger, Richard L.
AU - Elliott, Jeffrey A.
PY - 2008/1
Y1 - 2008/1
N2 - Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controlswomen (NC). Design: We measured plasma melatonin every 30 min from 1800-1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings). Setting: The study was conducted at a university hospital. Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated. Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood. Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores. Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.
AB - Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controlswomen (NC). Design: We measured plasma melatonin every 30 min from 1800-1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings). Setting: The study was conducted at a university hospital. Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated. Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood. Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores. Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.
UR - http://www.scopus.com/inward/record.url?scp=38149098462&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38149098462&partnerID=8YFLogxK
U2 - 10.1210/jc.2006-2853
DO - 10.1210/jc.2006-2853
M3 - Article
C2 - 18042653
AN - SCOPUS:38149098462
VL - 93
SP - 54
EP - 60
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 1
ER -