Increased melatonin and delayed offset in menopausal depression: Role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index

Barbara L. Parry, Charles J. Meliska, Diane L. Sorenson, Ana M. López, Luis F. Martínez, Sara Nowakowski, Richard L. Hauger, Jeffrey A. Elliott

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Context: The constellation of endocrine patterns accompanying menopausal depression remains incompletely characterized. Objective: Our objective was to test the hypothesis that the amplitude or phase (timing) of melatonin circadian rhythms differs in menopausal depressed patients (DP) vs. normal controlswomen (NC). Design: We measured plasma melatonin every 30 min from 1800-1000 h in dim light (<30 lux) or dark, serum gonadotropins and steroids (1800 and 0600 h), and mood (Hamilton and Beck depression ratings). Setting: The study was conducted at a university hospital. Participants and Setting: Twenty-nine (18 NC, 11 DP) peri- or postmenopausal women participated. Main Outcome Measures: We measured plasma melatonin (onset, offset, synthesis offset, duration, peak concentration, and area under the curve) and mood. Results: Multi- and univariate analyses of covariance showed that melatonin offset time was delayed (P = 0.045) and plasma melatonin was elevated in DP compared with NC (P = 0.044) across time intervals. Multiple regression analyses showed that years past menopause predicted melatonin duration and that melatonin duration, body mass index, years past menopause, FSH level, and sleep end time were significant predictors of baseline Hamilton (P = 0.0003) and Beck (P = 0.00004) depression scores. Conclusions: Increased melatonin secretion that is phase delayed into the morning characterized menopausal DP vs. NC. Years past menopause, FSH, sleep end time, and body mass index may modulate effects of altered melatonin secretion in menopausal depression.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number1
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Follicle Stimulating Hormone
Melatonin
Menopause
Sleep
Body Mass Index
Depression
Plasmas
Circadian Rhythm
Gonadotropins
Area Under Curve
Multivariate Analysis
Steroids
Regression Analysis
Outcome Assessment (Health Care)
Light
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Increased melatonin and delayed offset in menopausal depression : Role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. / Parry, Barbara L.; Meliska, Charles J.; Sorenson, Diane L.; López, Ana M.; Martínez, Luis F.; Nowakowski, Sara; Hauger, Richard L.; Elliott, Jeffrey A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 1, 01.2008, p. 54-60.

Research output: Contribution to journalArticle

Parry, Barbara L. ; Meliska, Charles J. ; Sorenson, Diane L. ; López, Ana M. ; Martínez, Luis F. ; Nowakowski, Sara ; Hauger, Richard L. ; Elliott, Jeffrey A. / Increased melatonin and delayed offset in menopausal depression : Role of years past menopause, follicle-stimulating hormone, sleep end time, and body mass index. In: Journal of Clinical Endocrinology and Metabolism. 2008 ; Vol. 93, No. 1. pp. 54-60.
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