Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat

Sang Chae Nam, Kwang Jin Kim, Joong Woo Leem, Kyungsoon Chung, Jin Mo Chung

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We examined the possibility that peripheral nerve injury in the adult rat triggers sprouting of unmyelinated ventral root afferent fibers. Three to 5 months after the sciatic nerve was sectioned on one side in the adult rat, myelinated and unmyelinated fibers were counted at 3 sites along the length of the ventral root. A sciatic nerve lesion resulted in about a 3-fold increase in the number of unmyelinated fibers in the L5 ventral root. Our data suggest that a peripheral nerve lesion in the adult rat triggers sprouting of unmyelinated afferent fibers in the ventral root. No evidence was found that dorsal rhizotomy triggers sprouting of afferent fibers.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalNeuroscience Letters
Volume116
Issue number1-2
DOIs
StatePublished - Aug 14 1990

Keywords

  • Dorsal rhizotomy
  • Peripheral nerve injury
  • Peripheral nerve sprouting
  • Spinal nerve
  • Unmyelinated fiber
  • Ventral root afferent

ASJC Scopus subject areas

  • Neuroscience(all)

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