Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat

Sang Chae Nam; Kwang Jin Kim; Joong Woo Leem; Kyungsoon Chung; Jin Mo Chung

doi:10.1016/0304-3940(90)90383-K

Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat

Sang Chae Nam, Kwang Jin Kim, Joong Woo Leem, Kyungsoon Chung, Jin Mo Chung

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We examined the possibility that peripheral nerve injury in the adult rat triggers sprouting of unmyelinated ventral root afferent fibers. Three to 5 months after the sciatic nerve was sectioned on one side in the adult rat, myelinated and unmyelinated fibers were counted at 3 sites along the length of the ventral root. A sciatic nerve lesion resulted in about a 3-fold increase in the number of unmyelinated fibers in the L₅ ventral root. Our data suggest that a peripheral nerve lesion in the adult rat triggers sprouting of unmyelinated afferent fibers in the ventral root. No evidence was found that dorsal rhizotomy triggers sprouting of afferent fibers.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Neuroscience Letters
Volume	116
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(90)90383-K
State	Published - Aug 14 1990

Keywords

Dorsal rhizotomy
Peripheral nerve injury
Peripheral nerve sprouting
Spinal nerve
Unmyelinated fiber
Ventral root afferent

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(90)90383-K

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@article{13d6effee1a94cd58b1ee93cf226dc09,

title = "Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat",

abstract = "We examined the possibility that peripheral nerve injury in the adult rat triggers sprouting of unmyelinated ventral root afferent fibers. Three to 5 months after the sciatic nerve was sectioned on one side in the adult rat, myelinated and unmyelinated fibers were counted at 3 sites along the length of the ventral root. A sciatic nerve lesion resulted in about a 3-fold increase in the number of unmyelinated fibers in the L5 ventral root. Our data suggest that a peripheral nerve lesion in the adult rat triggers sprouting of unmyelinated afferent fibers in the ventral root. No evidence was found that dorsal rhizotomy triggers sprouting of afferent fibers.",

keywords = "Dorsal rhizotomy, Peripheral nerve injury, Peripheral nerve sprouting, Spinal nerve, Unmyelinated fiber, Ventral root afferent",

author = "Nam, \{Sang Chae\} and Kim, \{Kwang Jin\} and Leem, \{Joong Woo\} and Kyungsoon Chung and Chung, \{Jin Mo\}",

note = "Funding Information: This work was supported by NIH Grants NS 21266 and NS 11255. J.M.C. is the recipient of NIH Research Career Development Award NS 00995. We wish to thank M.L. Watson for editorial help and H. Freeborn for art work and photography.",

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doi = "10.1016/0304-3940(90)90383-K",

language = "English (US)",

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pages = "40--44",

journal = "Neuroscience Letters",

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T1 - Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat

AU - Nam, Sang Chae

AU - Kim, Kwang Jin

AU - Leem, Joong Woo

AU - Chung, Kyungsoon

AU - Chung, Jin Mo

N1 - Funding Information: This work was supported by NIH Grants NS 21266 and NS 11255. J.M.C. is the recipient of NIH Research Career Development Award NS 00995. We wish to thank M.L. Watson for editorial help and H. Freeborn for art work and photography.

PY - 1990/8/14

Y1 - 1990/8/14

N2 - We examined the possibility that peripheral nerve injury in the adult rat triggers sprouting of unmyelinated ventral root afferent fibers. Three to 5 months after the sciatic nerve was sectioned on one side in the adult rat, myelinated and unmyelinated fibers were counted at 3 sites along the length of the ventral root. A sciatic nerve lesion resulted in about a 3-fold increase in the number of unmyelinated fibers in the L5 ventral root. Our data suggest that a peripheral nerve lesion in the adult rat triggers sprouting of unmyelinated afferent fibers in the ventral root. No evidence was found that dorsal rhizotomy triggers sprouting of afferent fibers.

AB - We examined the possibility that peripheral nerve injury in the adult rat triggers sprouting of unmyelinated ventral root afferent fibers. Three to 5 months after the sciatic nerve was sectioned on one side in the adult rat, myelinated and unmyelinated fibers were counted at 3 sites along the length of the ventral root. A sciatic nerve lesion resulted in about a 3-fold increase in the number of unmyelinated fibers in the L5 ventral root. Our data suggest that a peripheral nerve lesion in the adult rat triggers sprouting of unmyelinated afferent fibers in the ventral root. No evidence was found that dorsal rhizotomy triggers sprouting of afferent fibers.

KW - Dorsal rhizotomy

KW - Peripheral nerve injury

KW - Peripheral nerve sprouting

KW - Spinal nerve

KW - Unmyelinated fiber

KW - Ventral root afferent

UR - https://www.scopus.com/pages/publications/0025322929

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U2 - 10.1016/0304-3940(90)90383-K

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AN - SCOPUS:0025322929

SN - 0304-3940

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1-2

ER -

Increased number of unmyelinated fibers in the ventral root after peripheral neurectomy in adult rat

Abstract

Keywords

ASJC Scopus subject areas

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