Abstract
Mechanisms of central and peripheral tolerance prevent autoimmunity. Regulatory T cells inhibit the activation of potentially auto-reactive T cells in peripheral lymphoid organs. In transgenic mice in which all MHC class II molecules are incapable of binding to CD4, class II MHC-restricted T cells preferentially differentiated into immunosuppressive, regulatory T cells. In these mutant MHC class II transgenic mice, a subset of CD4+ T cells constitutively expressed moderately elevated levels of CD25 and potently inhibited interleukin-2 secretion by T cells from normal mice in a cell-to-cell, contact-dependent manner. Immunosuppressive activity depended on activation of the regulatory T cells. Thus, CD25+CD4+ T cells from mutant MHC class II transgenic mice resembled phenotypically and functionally a major subset of natural regulatory T cells in normal mice, but were two to three-times more abundant. These results further clarify the mechanisms that govern the differentiation and maintenance of CD25+CD4+ regulatory T cells, and present avenues for immunomodulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 117-128 |
| Number of pages | 12 |
| Journal | Cellular Immunology |
| Volume | 282 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2013 |
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Keywords
- Aging mice
- CD25
- CD4-MHC class II interactions
- CD95
- Effector/memory T cells
- Immunosuppression
- Naïve T cells
- Regulatory T cells
ASJC Scopus subject areas
- Immunology
Cite this
Increased numbers and suppressive activity of regulatory CD25+CD4+ T lymphocytes in the absence of CD4 engagement by MHC class II molecules. / Shen, Xiaoli; Niu, Chun; König, Rolf.
In: Cellular Immunology, Vol. 282, No. 2, 04.2013, p. 117-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased numbers and suppressive activity of regulatory CD25+CD4+ T lymphocytes in the absence of CD4 engagement by MHC class II molecules
AU - Shen, Xiaoli
AU - Niu, Chun
AU - König, Rolf
PY - 2013/4
Y1 - 2013/4
N2 - Mechanisms of central and peripheral tolerance prevent autoimmunity. Regulatory T cells inhibit the activation of potentially auto-reactive T cells in peripheral lymphoid organs. In transgenic mice in which all MHC class II molecules are incapable of binding to CD4, class II MHC-restricted T cells preferentially differentiated into immunosuppressive, regulatory T cells. In these mutant MHC class II transgenic mice, a subset of CD4+ T cells constitutively expressed moderately elevated levels of CD25 and potently inhibited interleukin-2 secretion by T cells from normal mice in a cell-to-cell, contact-dependent manner. Immunosuppressive activity depended on activation of the regulatory T cells. Thus, CD25+CD4+ T cells from mutant MHC class II transgenic mice resembled phenotypically and functionally a major subset of natural regulatory T cells in normal mice, but were two to three-times more abundant. These results further clarify the mechanisms that govern the differentiation and maintenance of CD25+CD4+ regulatory T cells, and present avenues for immunomodulation.
AB - Mechanisms of central and peripheral tolerance prevent autoimmunity. Regulatory T cells inhibit the activation of potentially auto-reactive T cells in peripheral lymphoid organs. In transgenic mice in which all MHC class II molecules are incapable of binding to CD4, class II MHC-restricted T cells preferentially differentiated into immunosuppressive, regulatory T cells. In these mutant MHC class II transgenic mice, a subset of CD4+ T cells constitutively expressed moderately elevated levels of CD25 and potently inhibited interleukin-2 secretion by T cells from normal mice in a cell-to-cell, contact-dependent manner. Immunosuppressive activity depended on activation of the regulatory T cells. Thus, CD25+CD4+ T cells from mutant MHC class II transgenic mice resembled phenotypically and functionally a major subset of natural regulatory T cells in normal mice, but were two to three-times more abundant. These results further clarify the mechanisms that govern the differentiation and maintenance of CD25+CD4+ regulatory T cells, and present avenues for immunomodulation.
KW - Aging mice
KW - CD25
KW - CD4-MHC class II interactions
KW - CD95
KW - Effector/memory T cells
KW - Immunosuppression
KW - Naïve T cells
KW - Regulatory T cells
UR - http://www.scopus.com/inward/record.url?scp=84879173791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879173791&partnerID=8YFLogxK
U2 - 10.1016/j.cellimm.2013.05.002
DO - 10.1016/j.cellimm.2013.05.002
M3 - Article
C2 - 23770721
AN - SCOPUS:84879173791
VL - 282
SP - 117
EP - 128
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 2
ER -