Increased potency and sustained suppressive actions of a new gonadotropin-releasing hormone (GnRH) antagonist peptide in man.

R. J. Urban; S. N. Pavlou; J. E. Rivier; W. W. Vale; M. L. Dufau; J. D. Veldhuis

Increased potency and sustained suppressive actions of a new gonadotropin-releasing hormone (GnRH) antagonist peptide in man.

R. J. Urban, S. N. Pavlou, J. E. Rivier, W. W. Vale, M. L. Dufau, J. D. Veldhuis

Research output: Contribution to journal › Article › peer-review

Abstract

We have used a new potent GnRH antagonist to assess the efficacy of suppression of gonadotropin secretion in healthy postmenopausal women at three different doses. The Nal-Glu antagonist produced significant suppression of immunoactive and bioactive LH at a 300 micrograms/kg dose throughout the 30-hr sampling interval with only minimal local (skin) histamine release. This increased potency and decreased skin reactivity of the Nal-Glu antagonist make it a drug with potential clinical use similar to the GnRH agonist, but with the advantage of immediate gonadotropin suppression.

Original language	English (US)
Pages (from-to)	302-309
Number of pages	8
Journal	Transactions of the Association of American Physicians
Volume	101
State	Published - 1988
Externally published	Yes

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abstract = "We have used a new potent GnRH antagonist to assess the efficacy of suppression of gonadotropin secretion in healthy postmenopausal women at three different doses. The Nal-Glu antagonist produced significant suppression of immunoactive and bioactive LH at a 300 micrograms/kg dose throughout the 30-hr sampling interval with only minimal local (skin) histamine release. This increased potency and decreased skin reactivity of the Nal-Glu antagonist make it a drug with potential clinical use similar to the GnRH agonist, but with the advantage of immediate gonadotropin suppression.",

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AU - Urban, R. J.

AU - Pavlou, S. N.

AU - Rivier, J. E.

AU - Vale, W. W.

AU - Dufau, M. L.

AU - Veldhuis, J. D.

PY - 1988

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AB - We have used a new potent GnRH antagonist to assess the efficacy of suppression of gonadotropin secretion in healthy postmenopausal women at three different doses. The Nal-Glu antagonist produced significant suppression of immunoactive and bioactive LH at a 300 micrograms/kg dose throughout the 30-hr sampling interval with only minimal local (skin) histamine release. This increased potency and decreased skin reactivity of the Nal-Glu antagonist make it a drug with potential clinical use similar to the GnRH agonist, but with the advantage of immediate gonadotropin suppression.

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JO - Transactions of the Association of American Physicians

JF - Transactions of the Association of American Physicians

ER -

Increased potency and sustained suppressive actions of a new gonadotropin-releasing hormone (GnRH) antagonist peptide in man.

Abstract

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