Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas

Kimberly M. Brown, Christinnah Domin, Gerard V. Aranha, Sherri Yong, Margo Shoup

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: Platelets are thought to participate in tumor metastasis. However, the relationship between platelet count and prognosis in pancreatic cancer remains unresolved. Methods: A chart review of patients undergoing resection for pancreatic adenocarcinoma was undertaken. Demographic, perioperative, and outcome data were collected. Kaplan-Meier survival and Cox regression analyses were used to determine the impact of preoperative platelet count on survival. Results: Between June 1995 and March 2003, 109 patients (63% male) with a median age of 68 years (range 42 to 85 years) underwent resection for pancreatic cancer. Univariate analysis demonstrated that platelet count, lymph node or margin status, and histology were associated with survival. In multivariate analysis, the association between increased platelet count and poor survival maintained significance. Conclusions: Increased preoperative platelet count is associated with adverse survival outcome in patients undergoing resection for pancreatic cancer. Antiplatelet medications warrant further study in an attempt to improve survival in these patients.

Original languageEnglish (US)
Pages (from-to)278-282
Number of pages5
JournalAmerican Journal of Surgery
Volume189
Issue number3
DOIs
StatePublished - Mar 2005
Externally publishedYes

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Platelet Count
Pancreas
Adenocarcinoma
Survival
Pancreatic Neoplasms
Histology
Blood Platelets
Multivariate Analysis
Lymph Nodes
Regression Analysis
Demography
Neoplasm Metastasis
Neoplasms

Keywords

  • Outcome
  • Pancreatic cancer
  • Platelets
  • Survival
  • Thrombocytosis

ASJC Scopus subject areas

  • Surgery

Cite this

Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. / Brown, Kimberly M.; Domin, Christinnah; Aranha, Gerard V.; Yong, Sherri; Shoup, Margo.

In: American Journal of Surgery, Vol. 189, No. 3, 03.2005, p. 278-282.

Research output: Contribution to journalArticle

Brown, Kimberly M. ; Domin, Christinnah ; Aranha, Gerard V. ; Yong, Sherri ; Shoup, Margo. / Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas. In: American Journal of Surgery. 2005 ; Vol. 189, No. 3. pp. 278-282.
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