Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

Frank C. Schmalstieg, J. Arly Nelson, Gordon C. Mills, Thomas M. Monahan, Armond S. Goldman, Randall M. Goldblum

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalThe Journal of pediatrics
Volume91
Issue number1
DOIs
StatePublished - 1977

Fingerprint

Purine Nucleotides
Nucleotides
Adenosine Triphosphate
Pyrimidine Nucleotides
Lymphocytes
Cyclic AMP
Adenosine Diphosphate
Severe combined immunodeficiency due to adenosine deaminase deficiency

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Schmalstieg, F. C., Nelson, J. A., Mills, G. C., Monahan, T. M., Goldman, A. S., & Goldblum, R. M. (1977). Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes. The Journal of pediatrics, 91(1), 48-51. https://doi.org/10.1016/S0022-3476(77)80442-3

Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes. / Schmalstieg, Frank C.; Nelson, J. Arly; Mills, Gordon C.; Monahan, Thomas M.; Goldman, Armond S.; Goldblum, Randall M.

In: The Journal of pediatrics, Vol. 91, No. 1, 1977, p. 48-51.

Research output: Contribution to journalArticle

Schmalstieg, FC, Nelson, JA, Mills, GC, Monahan, TM, Goldman, AS & Goldblum, RM 1977, 'Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes', The Journal of pediatrics, vol. 91, no. 1, pp. 48-51. https://doi.org/10.1016/S0022-3476(77)80442-3
Schmalstieg FC, Nelson JA, Mills GC, Monahan TM, Goldman AS, Goldblum RM. Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes. The Journal of pediatrics. 1977;91(1):48-51. https://doi.org/10.1016/S0022-3476(77)80442-3
Schmalstieg, Frank C. ; Nelson, J. Arly ; Mills, Gordon C. ; Monahan, Thomas M. ; Goldman, Armond S. ; Goldblum, Randall M. / Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes. In: The Journal of pediatrics. 1977 ; Vol. 91, No. 1. pp. 48-51.
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