Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

Frank C. Schmalstieg, J. Arly Nelson, Gordon C. Mills, Thomas M. Monahan, Armond S. Goldman, Randall M. Goldblum

Research output: Contribution to journalArticle

51 Scopus citations


It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.

Original languageEnglish (US)
Pages (from-to)48-51
Number of pages4
JournalThe Journal of Pediatrics
Issue number1
StatePublished - Jul 1977


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Schmalstieg, F. C., Nelson, J. A., Mills, G. C., Monahan, T. M., Goldman, A. S., & Goldblum, R. M. (1977). Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes. The Journal of Pediatrics, 91(1), 48-51.