Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

Frank C. Schmalstieg; J. Arly Nelson; Gordon C. Mills; Thomas M. Monahan; Armond S. Goldman; Randall M. Goldblum

doi:10.1016/S0022-3476(77)80442-3

Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

Frank C. Schmalstieg
, J. Arly Nelson
, Gordon C. Mills
, Thomas M. Monahan
, Armond S. Goldman
, Randall M. Goldblum

Pediatrics

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.

Original language	English (US)
Pages (from-to)	48-51
Number of pages	4
Journal	The Journal of Pediatrics
Volume	91
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(77)80442-3
State	Published - Jul 1977

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(77)80442-3

Cite this

@article{40b565f02dc34118bc12850f82112a54,

title = "Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes",

abstract = "It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.",

author = "Schmalstieg, \{Frank C.\} and Nelson, \{J. Arly\} and Mills, \{Gordon C.\} and Monahan, \{Thomas M.\} and Goldman, \{Armond S.\} and Goldblum, \{Randall M.\}",

note = "Funding Information: From the Departments of Pediatrics and Human Biological Chemistry and Genetics, The University of Texas Medical Branch, and Kettering-Meyer Laboratory, Southern Research Institute. Supported in part by National Institutes of Health Grant No. DHEW RR-00073-14, General Clinical Research Centers Branch, Division of Research Facilities and Resoumes, and National Institutes of Health Grant No. RO1-CA-17057. Dr. Sehmalstieg is the recipient of The Jeanne B. Kempner Scholarship Award, The University of Texas Medical Branch, Galveston, Texas. *Reprint address; Division of Immunology and Allergy, Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77550.",

year = "1977",

month = jul,

doi = "10.1016/S0022-3476(77)80442-3",

language = "English (US)",

volume = "91",

pages = "48--51",

journal = "The Journal of Pediatrics",

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TY - JOUR

T1 - Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

AU - Schmalstieg, Frank C.

AU - Nelson, J. Arly

AU - Mills, Gordon C.

AU - Monahan, Thomas M.

AU - Goldman, Armond S.

AU - Goldblum, Randall M.

N1 - Funding Information: From the Departments of Pediatrics and Human Biological Chemistry and Genetics, The University of Texas Medical Branch, and Kettering-Meyer Laboratory, Southern Research Institute. Supported in part by National Institutes of Health Grant No. DHEW RR-00073-14, General Clinical Research Centers Branch, Division of Research Facilities and Resoumes, and National Institutes of Health Grant No. RO1-CA-17057. Dr. Sehmalstieg is the recipient of The Jeanne B. Kempner Scholarship Award, The University of Texas Medical Branch, Galveston, Texas. *Reprint address; Division of Immunology and Allergy, Department of Pediatrics, The University of Texas Medical Branch, Galveston, TX 77550.

PY - 1977/7

Y1 - 1977/7

N2 - It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.

AB - It was found that ATP and cyclic AMP were greatly increased in human blood lymphocytes which weredeficient in ADA. Certain other purine and pyrimidine nucleotides were elevated but to a lesser degree. Energy production in these cells may be inhibited by the increase in nucleotides since the ATP:ADP ratio was significantly below normal. Thus it appears that the immunologic deficiency in human ADA deficiency is related to increased nucleotide concentrations in the lymphocytes.

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U2 - 10.1016/S0022-3476(77)80442-3

DO - 10.1016/S0022-3476(77)80442-3

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C2 - 195028

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EP - 51

JO - The Journal of Pediatrics

JF - The Journal of Pediatrics

IS - 1

ER -

Increased purine nucleotides in adenosinedeaminase-deficient lymphocytes

Abstract

ASJC Scopus subject areas

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