Increased resource use in lung transplant admissions in the lung allocation score era

Bryan G. Maxwell, Joshua J. Mooney, Peter H U Lee, Joseph E. Levitt, Laveena Chhatwani, Mark R. Nicolls, Martin R. Zamora, Vincent Valentine, David Weill, Gundeep S. Dhillon

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Rationale: In 2005, the lung allocation score (LAS) was implemented to prioritize organ allocation to minimize waiting-list mortality and maximize 1-year survival. It resulted in transplantation of older and sicker patients without changing 1-year survival. Its effect on resource use is unknown. Objectives: To determine changes in resource use over time in lung transplant admissions. Methods: Solid organ transplant recipients were identified within the Nationwide Inpatient Sample (NIS) data from 2000 to 2011. Joinpoint regression methodology was performed to identify a time point of change in mean total hospital charges among lung transplant and other solid-organ transplant recipients. Two temporal lung transplant recipient cohorts identified by joinpoint regression were compared for baseline characteristics and resource use, including total charges for index hospitalization, charges per day, length of stay, discharge disposition, tracheostomy, and need for extracorporeal membrane oxygenation. Measurements and Main Results: A significant point of increased total hospital charges occurred for lung transplant recipients in 2005, corresponding to LAS implementation, which was not seen in other solid-organ transplant recipients. Total transplant hospital charges increased by 40% in the post-LAS cohort ($569,942 [$53,229] vs. $407,489 [$28,360]) along with an increased median length of stay, daily charges, and discharge disposition other than to home. Post-LAS recipients also had higher post-transplant use of extracorporeal membrane oxygenation (odds ratio, 2.35; 95% confidence interval, 1.56-3.55) and higher incidence of tracheostomy (odds ratio, 1.52; 95% confidence interval, 1.22-1.89). Conclusions: LAS implementation is associated with a significant increase in resource use during index hospitalization for lung transplant.

Original languageEnglish (US)
Pages (from-to)302-308
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume191
Issue number3
DOIs
StatePublished - Feb 1 2015

Fingerprint

Transplants
Lung
Hospital Charges
Extracorporeal Membrane Oxygenation
Tracheostomy
Length of Stay
Hospitalization
Odds Ratio
Confidence Intervals
Waiting Lists
Survival
Inpatients
Transplantation
Transplant Recipients
Mortality
Incidence

Keywords

  • Lung allocation score
  • Lung transplant
  • Lung transplant cost
  • Nationwide Inpatient Sample
  • Solid-organ transplant

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Maxwell, B. G., Mooney, J. J., Lee, P. H. U., Levitt, J. E., Chhatwani, L., Nicolls, M. R., ... Dhillon, G. S. (2015). Increased resource use in lung transplant admissions in the lung allocation score era. American Journal of Respiratory and Critical Care Medicine, 191(3), 302-308. https://doi.org/10.1164/rccm.201408-1562OC

Increased resource use in lung transplant admissions in the lung allocation score era. / Maxwell, Bryan G.; Mooney, Joshua J.; Lee, Peter H U; Levitt, Joseph E.; Chhatwani, Laveena; Nicolls, Mark R.; Zamora, Martin R.; Valentine, Vincent; Weill, David; Dhillon, Gundeep S.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 191, No. 3, 01.02.2015, p. 302-308.

Research output: Contribution to journalArticle

Maxwell, BG, Mooney, JJ, Lee, PHU, Levitt, JE, Chhatwani, L, Nicolls, MR, Zamora, MR, Valentine, V, Weill, D & Dhillon, GS 2015, 'Increased resource use in lung transplant admissions in the lung allocation score era', American Journal of Respiratory and Critical Care Medicine, vol. 191, no. 3, pp. 302-308. https://doi.org/10.1164/rccm.201408-1562OC
Maxwell, Bryan G. ; Mooney, Joshua J. ; Lee, Peter H U ; Levitt, Joseph E. ; Chhatwani, Laveena ; Nicolls, Mark R. ; Zamora, Martin R. ; Valentine, Vincent ; Weill, David ; Dhillon, Gundeep S. / Increased resource use in lung transplant admissions in the lung allocation score era. In: American Journal of Respiratory and Critical Care Medicine. 2015 ; Vol. 191, No. 3. pp. 302-308.
@article{87bf0328014f465c9309ef0d0b2d0df2,
title = "Increased resource use in lung transplant admissions in the lung allocation score era",
abstract = "Rationale: In 2005, the lung allocation score (LAS) was implemented to prioritize organ allocation to minimize waiting-list mortality and maximize 1-year survival. It resulted in transplantation of older and sicker patients without changing 1-year survival. Its effect on resource use is unknown. Objectives: To determine changes in resource use over time in lung transplant admissions. Methods: Solid organ transplant recipients were identified within the Nationwide Inpatient Sample (NIS) data from 2000 to 2011. Joinpoint regression methodology was performed to identify a time point of change in mean total hospital charges among lung transplant and other solid-organ transplant recipients. Two temporal lung transplant recipient cohorts identified by joinpoint regression were compared for baseline characteristics and resource use, including total charges for index hospitalization, charges per day, length of stay, discharge disposition, tracheostomy, and need for extracorporeal membrane oxygenation. Measurements and Main Results: A significant point of increased total hospital charges occurred for lung transplant recipients in 2005, corresponding to LAS implementation, which was not seen in other solid-organ transplant recipients. Total transplant hospital charges increased by 40{\%} in the post-LAS cohort ($569,942 [$53,229] vs. $407,489 [$28,360]) along with an increased median length of stay, daily charges, and discharge disposition other than to home. Post-LAS recipients also had higher post-transplant use of extracorporeal membrane oxygenation (odds ratio, 2.35; 95{\%} confidence interval, 1.56-3.55) and higher incidence of tracheostomy (odds ratio, 1.52; 95{\%} confidence interval, 1.22-1.89). Conclusions: LAS implementation is associated with a significant increase in resource use during index hospitalization for lung transplant.",
keywords = "Lung allocation score, Lung transplant, Lung transplant cost, Nationwide Inpatient Sample, Solid-organ transplant",
author = "Maxwell, {Bryan G.} and Mooney, {Joshua J.} and Lee, {Peter H U} and Levitt, {Joseph E.} and Laveena Chhatwani and Nicolls, {Mark R.} and Zamora, {Martin R.} and Vincent Valentine and David Weill and Dhillon, {Gundeep S.}",
year = "2015",
month = "2",
day = "1",
doi = "10.1164/rccm.201408-1562OC",
language = "English (US)",
volume = "191",
pages = "302--308",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",

}

TY - JOUR

T1 - Increased resource use in lung transplant admissions in the lung allocation score era

AU - Maxwell, Bryan G.

AU - Mooney, Joshua J.

AU - Lee, Peter H U

AU - Levitt, Joseph E.

AU - Chhatwani, Laveena

AU - Nicolls, Mark R.

AU - Zamora, Martin R.

AU - Valentine, Vincent

AU - Weill, David

AU - Dhillon, Gundeep S.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Rationale: In 2005, the lung allocation score (LAS) was implemented to prioritize organ allocation to minimize waiting-list mortality and maximize 1-year survival. It resulted in transplantation of older and sicker patients without changing 1-year survival. Its effect on resource use is unknown. Objectives: To determine changes in resource use over time in lung transplant admissions. Methods: Solid organ transplant recipients were identified within the Nationwide Inpatient Sample (NIS) data from 2000 to 2011. Joinpoint regression methodology was performed to identify a time point of change in mean total hospital charges among lung transplant and other solid-organ transplant recipients. Two temporal lung transplant recipient cohorts identified by joinpoint regression were compared for baseline characteristics and resource use, including total charges for index hospitalization, charges per day, length of stay, discharge disposition, tracheostomy, and need for extracorporeal membrane oxygenation. Measurements and Main Results: A significant point of increased total hospital charges occurred for lung transplant recipients in 2005, corresponding to LAS implementation, which was not seen in other solid-organ transplant recipients. Total transplant hospital charges increased by 40% in the post-LAS cohort ($569,942 [$53,229] vs. $407,489 [$28,360]) along with an increased median length of stay, daily charges, and discharge disposition other than to home. Post-LAS recipients also had higher post-transplant use of extracorporeal membrane oxygenation (odds ratio, 2.35; 95% confidence interval, 1.56-3.55) and higher incidence of tracheostomy (odds ratio, 1.52; 95% confidence interval, 1.22-1.89). Conclusions: LAS implementation is associated with a significant increase in resource use during index hospitalization for lung transplant.

AB - Rationale: In 2005, the lung allocation score (LAS) was implemented to prioritize organ allocation to minimize waiting-list mortality and maximize 1-year survival. It resulted in transplantation of older and sicker patients without changing 1-year survival. Its effect on resource use is unknown. Objectives: To determine changes in resource use over time in lung transplant admissions. Methods: Solid organ transplant recipients were identified within the Nationwide Inpatient Sample (NIS) data from 2000 to 2011. Joinpoint regression methodology was performed to identify a time point of change in mean total hospital charges among lung transplant and other solid-organ transplant recipients. Two temporal lung transplant recipient cohorts identified by joinpoint regression were compared for baseline characteristics and resource use, including total charges for index hospitalization, charges per day, length of stay, discharge disposition, tracheostomy, and need for extracorporeal membrane oxygenation. Measurements and Main Results: A significant point of increased total hospital charges occurred for lung transplant recipients in 2005, corresponding to LAS implementation, which was not seen in other solid-organ transplant recipients. Total transplant hospital charges increased by 40% in the post-LAS cohort ($569,942 [$53,229] vs. $407,489 [$28,360]) along with an increased median length of stay, daily charges, and discharge disposition other than to home. Post-LAS recipients also had higher post-transplant use of extracorporeal membrane oxygenation (odds ratio, 2.35; 95% confidence interval, 1.56-3.55) and higher incidence of tracheostomy (odds ratio, 1.52; 95% confidence interval, 1.22-1.89). Conclusions: LAS implementation is associated with a significant increase in resource use during index hospitalization for lung transplant.

KW - Lung allocation score

KW - Lung transplant

KW - Lung transplant cost

KW - Nationwide Inpatient Sample

KW - Solid-organ transplant

UR - http://www.scopus.com/inward/record.url?scp=84922324437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922324437&partnerID=8YFLogxK

U2 - 10.1164/rccm.201408-1562OC

DO - 10.1164/rccm.201408-1562OC

M3 - Article

C2 - 25517213

AN - SCOPUS:84922324437

VL - 191

SP - 302

EP - 308

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3

ER -