Increased sensitivity to prostaglandin E2 in old people

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Prostaglandin E2 acts as a feedback inhibitor on the actions of many hormones and other stimuli. For example, mitogens will cause leukocytes to produce prostaglandin E2, and the prostaglandin E2 inhibits the proliferative response of the leukocytes to the mitogen. We have shown that lymphocytes from healthy subjects over age 70 are much more sensitive to inhibition by prostaglandin E2 than are lymphocytes from younger individuals. In this paper, I hypothesize that there is a generalized increase in sensitivity in all tissues in aging humans, and that this increased sensitivity accounts for many of the physiologic changes of aging.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalProstaglandines and Medicine
Volume3
Issue number6
DOIs
StatePublished - Dec 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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