Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Diosely C. Silveira; Gregory L. Holmes; Steven C. Schachter; Changiz Geula; Donald L. Schomer

doi:10.1016/S0006-8993(00)02703-7

Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Diosely C. Silveira, Gregory L. Holmes, Steven C. Schachter, Changiz Geula, Donald L. Schomer

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	223-227
Number of pages	5
Journal	Brain Research
Volume	878
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02703-7
State	Published - Sep 29 2000
Externally published	Yes

Keywords

Cholinergic system
Epilepsy
Flurothyl
Pentylenetetrazole
Saporin

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02703-7

Cite this

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title = "Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats",

abstract = "We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.",

keywords = "Cholinergic system, Epilepsy, Flurothyl, Pentylenetetrazole, Saporin",

author = "Silveira, {Diosely C.} and Holmes, {Gregory L.} and Schachter, {Steven C.} and Changiz Geula and Schomer, {Donald L.}",

note = "Funding Information: This work was supported by NIH grant (NS27984) to GLH and the Emily P. Rogers Research Fund.",

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T1 - Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

AU - Silveira, Diosely C.

AU - Holmes, Gregory L.

AU - Schachter, Steven C.

AU - Geula, Changiz

AU - Schomer, Donald L.

N1 - Funding Information: This work was supported by NIH grant (NS27984) to GLH and the Emily P. Rogers Research Fund.

PY - 2000/9/29

Y1 - 2000/9/29

N2 - We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

AB - We investigated whether basal forebrain cholinergic neurons influence the expression of generalized seizures. Animals received intracerebroventricular injections of saporin (lesioned) or saline (controls) and were tested for susceptibility to flurothyl- or pentylenetetrazole-induced seizures. Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures. (C) 2000 Elsevier Science B.V.

KW - Cholinergic system

KW - Epilepsy

KW - Flurothyl

KW - Pentylenetetrazole

KW - Saporin

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JO - Brain Research

JF - Brain Research

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ER -

Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats

Abstract

Keywords

ASJC Scopus subject areas

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