Increased thromboxane B2 levels in the plasma of burned and septic burned patients

D. N. Herndon, S. Abston, M. D. Stein

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Levels of both thromboxane B2 and 6-keto-prostaglandin-F(1a), the stable metabolites of thromboxane A2 and prostacyclin, respectively, were quantitated in plasma samples from burn patients at various times postinjury. Our results indicate that, although thromboxane B2 levels were elevated throughout the burn course, quite large increases occurred both in the acute stage (less than three days postinjury) and during septic episodes. The results of our study demonstrate that, at the same time thromboxane B2 levels were evaluated, 6-keto-prostaglandin-F(1a) levels were unchanged and remained at control levels. Increased production of thromboxane B2 without a concomitant increase in 6-keto-prostaglandin-F(1a) in the plasma of burn patients gives support to the hypothesis that elevated thromboxane A2 production contributes to post-thermal injury systemic responses, both in the acute phase as well as during sepsis.

Original languageEnglish (US)
Pages (from-to)210-213
Number of pages4
JournalSurgery Gynecology and Obstetrics
Volume159
Issue number3
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

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