Increased thromboxane B₂ levels in the plasma of burned and septic burned patients

Levels of both thromboxane B₂ and 6-keto-prostaglandin-F(1a), the stable metabolites of thromboxane A₂ and prostacyclin, respectively, were quantitated in plasma samples from burn patients at various times postinjury. Our results indicate that, although thromboxane B₂ levels were elevated throughout the burn course, quite large increases occurred both in the acute stage (less than three days postinjury) and during septic episodes. The results of our study demonstrate that, at the same time thromboxane B₂ levels were evaluated, 6-keto-prostaglandin-F(1a) levels were unchanged and remained at control levels. Increased production of thromboxane B₂ without a concomitant increase in 6-keto-prostaglandin-F(1a) in the plasma of burn patients gives support to the hypothesis that elevated thromboxane A₂ production contributes to post-thermal injury systemic responses, both in the acute phase as well as during sepsis.