Increased VLDL-TAG Turnover during and after Acute Moderate-Intensity Exercise

Béatrice Morio, Ulf Holmbäck, Dennis Gore, Robert R. Wolfe

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Purpose and Methods: Breakdown rates of very low density lipoprotein triacylglycerols (VLDL-TAG) were quantified before (3 h), during (45 min), and after (3 h) moderate physical exercise at 40% V̇O2max in young sedentary subjects (four male and four female, age 29.8 ± 1.6 yr, BMI 24.1 ± 0.9 kg·m-2, V̇O2max 37.0 ± 1.7 mL·kg-1·min-1), using boluses of 2H5-glycerol (100 μmol·kg-1) and 2H2-palmite (6.6 μmol·kg-1). The catabolic rates of VLDL-TAG were calculated from the decay in the isotopic enrichment using a single-pool model. The results were compared with those obtained during 6 h of rest in five of the same volunteers. Results: VLDL-TAG concentration remained constant throughout the study with exercise (P = NS). The fractional catabolic rate was nearly doubled from rest to exercise (P < 0.05 vs rest) and increased to an even greater extent during the early phase of recovery (P < 0.001 vs rest). During the late recovery phase, the value returned to the preexercise value (P = NS vs rest). The values for the absolute catabolic rate (kabs) followed the same trend. Conclusion: VLDL-TAG turnover was increased during exercise and during the early phase of recovery.

Original languageEnglish (US)
Pages (from-to)801-806
Number of pages6
JournalMedicine and Science in Sports and Exercise
Issue number5
StatePublished - May 2004


  • Energy metabolism
  • Human subjects
  • Lipid metabolism
  • Stable isotopes
  • Substrate oxidation

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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