Indeterminate fine-needle aspiration biopsy of the thyroid

Identification of subgroups at high risk for invasive carcinoma

Douglas Tyler, David J. Winchester, Nancy P. Caraway, Robert C. Hickey, Douglas B. Evans

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Background. We examined the various cytologic features of indeterminate thyroid fine-needle aspirates along with known clinical and radiologic risk factors to determine whether any parameters were predictive of malignancy. Methods. Indeterminate fine-needle aspirates were prospectively categorized into four subgroups: (1) suspicious for papillary carcinoma, (2) follicular neoplasm, (3) Hürthle cell neoplasm, and (4) hypercellular follicular aspirates with colloid. Several clinical risk factors were examined, and subgroup comparisons were performed with Fisher's exact test. Results. Of 571 fine-needle aspirate cytologic findings 104 were interpreted as indeterminate for malignancy, and 81 patients underwent thyroidectomy. Invasive cancer was diagnosed in 9 of 10 lesions cytologically suspicious for papillary -arcinoma, 8 of 43 follicular neoplasms, 5 of 18 Hürthle cell neoplasms, and 0 of 10 hypercellular aspirates. Cytologic subgroup (p < 0.0001) and age of 50 years or older (p = 0.008) were the only significant predictors of malignancy. When used together, age of 50 years or older and a cytologic diagnosis of follicular or Hürthle cell neoplasm also identified a subgroup of patients at high risk (9 of 20) of invasive malignancy (P = 0.01). Conclusions. The majority of invasive cancers (18 of 22, 82%) were found in patients whose lesions were suspicious for papillary carcinoma or in patients 50 years or older with follicular or Hürthle cell neoplasms. The risk of carcinoma in these combined subgroups (18 of 30, 60%) warrants early surgical intervention.

Original languageEnglish (US)
Pages (from-to)1054-1060
Number of pages7
JournalSurgery
Volume116
Issue number6
StatePublished - 1994
Externally publishedYes

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Fine Needle Biopsy
Thyroid Gland
Carcinoma
Neoplasms
Needles
Carcinoma, Papillary, Follicular
Papillary Carcinoma
Thyroidectomy
Colloids

ASJC Scopus subject areas

  • Surgery

Cite this

Tyler, D., Winchester, D. J., Caraway, N. P., Hickey, R. C., & Evans, D. B. (1994). Indeterminate fine-needle aspiration biopsy of the thyroid: Identification of subgroups at high risk for invasive carcinoma. Surgery, 116(6), 1054-1060.

Indeterminate fine-needle aspiration biopsy of the thyroid : Identification of subgroups at high risk for invasive carcinoma. / Tyler, Douglas; Winchester, David J.; Caraway, Nancy P.; Hickey, Robert C.; Evans, Douglas B.

In: Surgery, Vol. 116, No. 6, 1994, p. 1054-1060.

Research output: Contribution to journalArticle

Tyler, D, Winchester, DJ, Caraway, NP, Hickey, RC & Evans, DB 1994, 'Indeterminate fine-needle aspiration biopsy of the thyroid: Identification of subgroups at high risk for invasive carcinoma', Surgery, vol. 116, no. 6, pp. 1054-1060.
Tyler, Douglas ; Winchester, David J. ; Caraway, Nancy P. ; Hickey, Robert C. ; Evans, Douglas B. / Indeterminate fine-needle aspiration biopsy of the thyroid : Identification of subgroups at high risk for invasive carcinoma. In: Surgery. 1994 ; Vol. 116, No. 6. pp. 1054-1060.
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abstract = "Background. We examined the various cytologic features of indeterminate thyroid fine-needle aspirates along with known clinical and radiologic risk factors to determine whether any parameters were predictive of malignancy. Methods. Indeterminate fine-needle aspirates were prospectively categorized into four subgroups: (1) suspicious for papillary carcinoma, (2) follicular neoplasm, (3) H{\"u}rthle cell neoplasm, and (4) hypercellular follicular aspirates with colloid. Several clinical risk factors were examined, and subgroup comparisons were performed with Fisher's exact test. Results. Of 571 fine-needle aspirate cytologic findings 104 were interpreted as indeterminate for malignancy, and 81 patients underwent thyroidectomy. Invasive cancer was diagnosed in 9 of 10 lesions cytologically suspicious for papillary -arcinoma, 8 of 43 follicular neoplasms, 5 of 18 H{\"u}rthle cell neoplasms, and 0 of 10 hypercellular aspirates. Cytologic subgroup (p < 0.0001) and age of 50 years or older (p = 0.008) were the only significant predictors of malignancy. When used together, age of 50 years or older and a cytologic diagnosis of follicular or H{\"u}rthle cell neoplasm also identified a subgroup of patients at high risk (9 of 20) of invasive malignancy (P = 0.01). Conclusions. The majority of invasive cancers (18 of 22, 82{\%}) were found in patients whose lesions were suspicious for papillary carcinoma or in patients 50 years or older with follicular or H{\"u}rthle cell neoplasms. The risk of carcinoma in these combined subgroups (18 of 30, 60{\%}) warrants early surgical intervention.",
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AU - Evans, Douglas B.

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