Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus.

C. J. Trahan, James LeDuc, E. C. Staley, L. N. Binn, R. H. Marchwicki, S. M. Lemon, C. M. Keenan, W. H. Bancroft

Research output: Contribution to journalArticle

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Abstract

Several species of nonhuman primates have served as animal models for hepatitis A virus (HAV) infection and disease. This study was to determine the suitability of Aotus trivirgatus as an orally induced model for HAV infection and to reconfirm the owl monkey's susceptibility to the intravenous route of inoculation. Animals were inoculated, either orally or intravenously, with varying concentrations of PA-33 strain of HAV. Serum enzymes ALT, AST and GGTP levels were monitored and liver biopsies performed when values exceeded three standard deviations above individualized mean baseline values. All animals had postinoculation elevations of serum ALT and AST values, shed virus in their feces, and were seropositive to HAV by 60 days after inoculation. Eight of the ten postinoculation biopsy specimens had histologic lesions compatible with acute viral hepatitis. We conclude that the owl monkey is a useful and valuable model for the study of HAV disease.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalLaboratory animal science Chicago
Volume37
Issue number1
StatePublished - Feb 1987
Externally publishedYes

Fingerprint

Aotus trivirgatus
Aotidae
Aotus (Cebidae)
Hepatitis A virus
Viruses
Virus Diseases
mouth
Infection
infection
Animals
Biopsy
biopsy
Animal Hepatitis
viral hepatitis
gamma-Glutamyltransferase
sheds
Serum
Feces
lesions (animal)
normal values

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Trahan, C. J., LeDuc, J., Staley, E. C., Binn, L. N., Marchwicki, R. H., Lemon, S. M., ... Bancroft, W. H. (1987). Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus. Laboratory animal science Chicago, 37(1), 45-50.

Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus. / Trahan, C. J.; LeDuc, James; Staley, E. C.; Binn, L. N.; Marchwicki, R. H.; Lemon, S. M.; Keenan, C. M.; Bancroft, W. H.

In: Laboratory animal science Chicago, Vol. 37, No. 1, 02.1987, p. 45-50.

Research output: Contribution to journalArticle

Trahan, CJ, LeDuc, J, Staley, EC, Binn, LN, Marchwicki, RH, Lemon, SM, Keenan, CM & Bancroft, WH 1987, 'Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus.', Laboratory animal science Chicago, vol. 37, no. 1, pp. 45-50.
Trahan CJ, LeDuc J, Staley EC, Binn LN, Marchwicki RH, Lemon SM et al. Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus. Laboratory animal science Chicago. 1987 Feb;37(1):45-50.
Trahan, C. J. ; LeDuc, James ; Staley, E. C. ; Binn, L. N. ; Marchwicki, R. H. ; Lemon, S. M. ; Keenan, C. M. ; Bancroft, W. H. / Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus. In: Laboratory animal science Chicago. 1987 ; Vol. 37, No. 1. pp. 45-50.
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