Induced oral infection of the owl monkey (Aotus trivirgatus) with hepatitis A virus.

C. J. Trahan, J. W. LeDuc, E. C. Staley, L. N. Binn, R. H. Marchwicki, S. M. Lemon, C. M. Keenan, W. H. Bancroft

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Several species of nonhuman primates have served as animal models for hepatitis A virus (HAV) infection and disease. This study was to determine the suitability of Aotus trivirgatus as an orally induced model for HAV infection and to reconfirm the owl monkey's susceptibility to the intravenous route of inoculation. Animals were inoculated, either orally or intravenously, with varying concentrations of PA-33 strain of HAV. Serum enzymes ALT, AST and GGTP levels were monitored and liver biopsies performed when values exceeded three standard deviations above individualized mean baseline values. All animals had postinoculation elevations of serum ALT and AST values, shed virus in their feces, and were seropositive to HAV by 60 days after inoculation. Eight of the ten postinoculation biopsy specimens had histologic lesions compatible with acute viral hepatitis. We conclude that the owl monkey is a useful and valuable model for the study of HAV disease.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalLaboratory animal science Chicago
Issue number1
StatePublished - Feb 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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