Induced Synthesis of Mycolactone Restores the Pathogenesis of Mycobacterium ulcerans In Vitro and In Vivo

Biochemistry, Genetics and Molecular Biology

• Mycobacterium ulcerans 100%
• Wild Type 50%
• Virulence Factor 50%
• Cell Culture 50%
• Macrophage 50%
• Autophagy 50%
• Mechanistic Target of Rapamycin 50%
• Gene Expression System 50%
• Immune Response 50%
• Life Cycle 50%
• Transposable Element 50%
• Transferase 50%
• Polyketide 50%
• Programmed Cell Death 50%

Keyphrases

• Induced Production 100%
• Mycobacterium Ulcerans 100%
• Mycolactone 100%
• M. Ulcerans 76%
• Buruli Ulcer 15%
• Apoptosis 7%
• Signaling Pathway 7%
• Macrophages 7%
• Virulence Factors 7%
• Extracellular Milieu 7%
• Host Response 7%
• Cell Culture Model 7%
• Mammalian Target of Rapamycin (mTOR) 7%
• Autophagy 7%
• Expression System 7%
• Cellular Processes 7%
• Vector System 7%
• Causative Agents 7%
• Further Analysis 7%
• Inducible System 7%
• Footpad 7%
• Infection Model 7%
• In Vitro Growth 7%
• Transferases 7%
• Tetracycline-inducible 7%
• Transposon Insertion 7%
• Mycobacterial Infection 7%
• Growth Defects 7%
• Polyketides 7%
• Target of Rapamycin Signalling 7%
• Response Modulation 7%
• Necrotic Ulcer 7%
• Intracellular Life Cycle 7%
• Bacterial Activation 7%
• Inducible Vector 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Ranitidine 100%
• Mycobacterium ulcerans 100%
• Infection 90%
• Buruli Ulcer 20%
• Transferase 10%
• Virulence Factor 10%
• Cell Culture 10%
• Tetracycline 10%
• Mammalian Target of Rapamycin 10%
• Ulcer 10%
• Cellular Processes 10%
• Polyketide 10%