Induction and expression rules of synaptic plasticity in hippocampal interneurons

Fernanda Laezza, Raymond Dingledine

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The knowledge that excitatory synapses on aspiny hippocampal interneurons can develop genuine forms of activity-dependent remodeling, independently from the surrounding network of principal cells, is a relatively new concept. Cumulative evidence has now unequivocally demonstrated that, despite the absence of specialized postsynaptic spines that serve as compartmentalized structure for intracellular signaling in principal cell plasticity, excitatory inputs onto interneurons can undergo forms of synaptic plasticity that are induced and expressed autonomously from principal cells. Yet, the rules for induction and expression of interneuron plasticity are much more heterogeneous than in principal neurons. Long-term plasticity in interneurons is not necessarily dependent upon postsynaptic activation of NMDA receptors nor relies on the same postsynaptic membrane potential requirements as principal cells. Plasticity in interneurons rather requires activation of Ca2+-permeable AMPA receptors and/or metabotropic glutamate receptors and is triggered by postsynaptic hyperpolarization. In this review we will outline these distinct features of interneuron plasticity and identify potential critical candidate molecules that might be important for sustaining long-lasting changes in synaptic strength at excitatory inputs onto interneurons. This article is part of a Special Issue entitled 'Synaptic Plasticity & Interneurons'.

Original languageEnglish (US)
Pages (from-to)720-729
Number of pages10
JournalNeuropharmacology
Volume60
Issue number5
DOIs
StatePublished - Apr 2011

Fingerprint

Neuronal Plasticity
Interneurons
Synaptic Potentials
Metabotropic Glutamate Receptors
AMPA Receptors
N-Methyl-D-Aspartate Receptors
Membrane Potentials
Synapses
Spine
Neurons

Keywords

  • GABA
  • Hippocampus
  • Interneurons
  • Plasticity
  • Synapses

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Induction and expression rules of synaptic plasticity in hippocampal interneurons. / Laezza, Fernanda; Dingledine, Raymond.

In: Neuropharmacology, Vol. 60, No. 5, 04.2011, p. 720-729.

Research output: Contribution to journalArticle

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