Abstract
When a bacterial immunopotentiator, OK-432, was injected to intact DDI mice, a viral inhibitor with the properties of immune interferon (IF) was induced in the circulation. The maximum titer of antiviral activity (10,240 units/ml) was observed 24 h after intraperitoneal (IP) injection of 50 KE OK-432/kg body weight. The possibility that the induction of immune IF may depend upon the action of thymus-derived (T) lymphocytes and macrophages was inferred from experiments with thymus-defective nude mice and DDI mice treated with either X-rays or immunosuppressive agents.
Original language | English (US) |
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Pages (from-to) | 41-45 |
Number of pages | 5 |
Journal | Cancer Immunology Immunotherapy |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Apr 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology
- Cancer Research