Induction of immune interferon in mice treated with a bacterial immunopotentiator, OK-432

Shuzo Matsubara, Fujio Suzuki, Nakao Ishida

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

When a bacterial immunopotentiator, OK-432, was injected to intact DDI mice, a viral inhibitor with the properties of immune interferon (IF) was induced in the circulation. The maximum titer of antiviral activity (10,240 units/ml) was observed 24 h after intraperitoneal (IP) injection of 50 KE OK-432/kg body weight. The possibility that the induction of immune IF may depend upon the action of thymus-derived (T) lymphocytes and macrophages was inferred from experiments with thymus-defective nude mice and DDI mice treated with either X-rays or immunosuppressive agents.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalCancer Immunology Immunotherapy
Volume6
Issue number1
DOIs
StatePublished - Apr 1979
Externally publishedYes

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Picibanil
Immunologic Adjuvants
Thymus Gland
Interferon-gamma
Immunosuppressive Agents
Intraperitoneal Injections
Nude Mice
Antiviral Agents
Macrophages
Body Weight
X-Rays
T-Lymphocytes

ASJC Scopus subject areas

  • Oncology
  • Immunology
  • Cancer Research

Cite this

Induction of immune interferon in mice treated with a bacterial immunopotentiator, OK-432. / Matsubara, Shuzo; Suzuki, Fujio; Ishida, Nakao.

In: Cancer Immunology Immunotherapy, Vol. 6, No. 1, 04.1979, p. 41-45.

Research output: Contribution to journalArticle

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