Abstract
The purpose of the present study was to compare the dose-response relationships for the induction of lung tumors in RFM mice after localized thoracic exposures to X rays or fission neutrons. Animals were killed 9 months after localized irradiation, their lungs were cleared, and the tumors were counted to determine both percentage incidence and tumors/mouse. From these data, the relationship between tumors/mouse and X-ray dose could be described adequately by a linear-quadratic model with a shallow initial slope, or by a threshold model with a dose-squared response above the threshold dose, and linearity could be rejected over the dose range of 0 to 900 rad. For neutrons the relationship between tumors/mouse and dose over the range of 0 to 25 rad could be described by a linear, or a threshold model with linear response above the threshold. In either case, the relative biological effectiveness increased with decreasing neutron dose from 25 at 25 rad to 40 at 10 rad.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 464-473 |
| Number of pages | 10 |
| Journal | Radiation research |
| Volume | 80 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Radiation
- Radiology Nuclear Medicine and imaging