TY - JOUR
T1 - Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors
AU - Yang, Huan
AU - Goluszko, Elzbieta
AU - David, Chella
AU - Okita, David K.
AU - Conti-Fine, Bianca
AU - Chan, Teh Sheng
AU - Poussin, Mathilde A.
AU - Christadoss, Premkumar
PY - 2003
Y1 - 2003
N2 - We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR α subunit. The cytoplasmic H-AChR peptide α320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8XDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8XDR3 F1 and DQ8XDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
AB - We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR α subunit. The cytoplasmic H-AChR peptide α320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8XDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8XDR3 F1 and DQ8XDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
KW - AChR
KW - Experimental autoimmune myasthenia gravis (EAMG)
KW - HLA transgenic mice
KW - Myasthenia gravis (MG)
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U2 - 10.1196/annals.1254.044
DO - 10.1196/annals.1254.044
M3 - Article
C2 - 14592899
AN - SCOPUS:0141504310
VL - 998
SP - 375
EP - 378
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -