Abstract
We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR α subunit. The cytoplasmic H-AChR peptide α320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8XDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8XDR3 F1 and DQ8XDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
Original language | English (US) |
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Pages (from-to) | 375-378 |
Number of pages | 4 |
Journal | Annals of the New York Academy of Sciences |
Volume | 998 |
DOIs | |
State | Published - 2003 |
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Keywords
- AChR
- Experimental autoimmune myasthenia gravis (EAMG)
- HLA transgenic mice
- Myasthenia gravis (MG)
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors. / Yang, Huan; Goluszko, Elzbieta; David, Chella; Okita, David K.; Conti-Fine, Bianca; Chan, Teh Sheng; Poussin, Mathilde A.; Christadoss, Premkumar.
In: Annals of the New York Academy of Sciences, Vol. 998, 2003, p. 375-378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors
AU - Yang, Huan
AU - Goluszko, Elzbieta
AU - David, Chella
AU - Okita, David K.
AU - Conti-Fine, Bianca
AU - Chan, Teh Sheng
AU - Poussin, Mathilde A.
AU - Christadoss, Premkumar
PY - 2003
Y1 - 2003
N2 - We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR α subunit. The cytoplasmic H-AChR peptide α320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8XDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8XDR3 F1 and DQ8XDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
AB - We utilized HLA transgenic mice to identify the dominant epitopes on the human (H)-AChR α subunit. The cytoplasmic H-AChR peptide α320-337 was the dominant T cell epitope for DQ8, DR3, and DQ8XDQ6 F1 mice. The H-AChR-immunized HLA-DQ8, DR3, DQ8XDR3 F1 and DQ8XDQ6 F1 mice developed clinical EAMG, whereas HLA-DQ6 mice were less susceptible.
KW - AChR
KW - Experimental autoimmune myasthenia gravis (EAMG)
KW - HLA transgenic mice
KW - Myasthenia gravis (MG)
UR - http://www.scopus.com/inward/record.url?scp=0141504310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141504310&partnerID=8YFLogxK
U2 - 10.1196/annals.1254.044
DO - 10.1196/annals.1254.044
M3 - Article
C2 - 14592899
AN - SCOPUS:0141504310
VL - 998
SP - 375
EP - 378
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
ER -