Infants and young children with cystic fibrosis have high levels of serum sialyl Lewisa antigen

R. C. Frates, S. Scott, K. B. Hammond, J. O. Brooks, Carol Richardson, D. D. Roberts

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previous studies suggest that serum levels of the mucin-associated sialyl Lewisa (Lea) antigen (NeuACα2-3 Galβ1-3 [Fucα1-4]GlcNAcβ1...) correlate with the pulmonary status of cystic fibrosis (CF) patients who have Lea or Lewisb blood types and can form the antigen. However, there is little information on serum sialyl Lea antigen levels in CF patients or normal children younger than 9 y. We measured serum antigen levels using the MAb 19- 9 in normal term neonates, CF infants and young children, and infants and children who had bronchopulmonary dysplasia or asthma. The mean serum sialyl Lea antigen level of the CF patients was 46.7 U/mL, significantly above (p < 0.01) the mean levels of the three other groups. The mean serum sialyl Lea levels of the three non-CF groups were not significantly different from one another or from published normal values. We conclude that serum sialyl Lea antigen levels are elevated early in CF, but are normal in asthma and bronchopulmonary dysplasia patients.

Original languageEnglish (US)
Pages (from-to)460-464
Number of pages5
JournalPediatric Research
Volume37
Issue number4 I
StatePublished - 1995

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Cystic Fibrosis
Antigens
Serum
Bronchopulmonary Dysplasia
Calgranulin A
Asthma
Mucins
Reference Values
Fibrosis
Newborn Infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Frates, R. C., Scott, S., Hammond, K. B., Brooks, J. O., Richardson, C., & Roberts, D. D. (1995). Infants and young children with cystic fibrosis have high levels of serum sialyl Lewisa antigen. Pediatric Research, 37(4 I), 460-464.

Infants and young children with cystic fibrosis have high levels of serum sialyl Lewisa antigen. / Frates, R. C.; Scott, S.; Hammond, K. B.; Brooks, J. O.; Richardson, Carol; Roberts, D. D.

In: Pediatric Research, Vol. 37, No. 4 I, 1995, p. 460-464.

Research output: Contribution to journalArticle

Frates, RC, Scott, S, Hammond, KB, Brooks, JO, Richardson, C & Roberts, DD 1995, 'Infants and young children with cystic fibrosis have high levels of serum sialyl Lewisa antigen', Pediatric Research, vol. 37, no. 4 I, pp. 460-464.
Frates, R. C. ; Scott, S. ; Hammond, K. B. ; Brooks, J. O. ; Richardson, Carol ; Roberts, D. D. / Infants and young children with cystic fibrosis have high levels of serum sialyl Lewisa antigen. In: Pediatric Research. 1995 ; Vol. 37, No. 4 I. pp. 460-464.
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