Previous studies suggest that serum levels of the mucin-associated sialyl Lewisa (Lea) antigen (NeuACα2-3 Galβ1-3 [Fucαl-4]GlcNAcβ1…) correlate with the pulmonary status of cystic fibrosis (CF) patients who have Lea or Lewisb blood types and can form the antigen. However, there is little information on serum sialyl Lea antigen levels in CF patients or normal children younger than 9 y. We measured serum antigen levels using the MAb 19-9 in normal term neonates, CF infants and young children, and infants and children who had bronchopulmonary dysplasia or asthma. The mean serum sialyl Lea antigen level of the CF patients was 46.7 U/mL, significantly above (p < 0.01) the mean levels of the three other groups. The mean serum sialyl Lea levels of the three non-CF groups were not significantly different from one another or from published normal values. We conclude that serum sialyl Lea antigen levels are elevated early in CF, but are normal in asthma and bronchopulmonary dysplasia patients.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health