Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum

Odilon Nouatin, Komi Gbedande, Akanni Adededji Abdoul Ibitokou, Bertin Vianou, Parfait Houngbegnon, Sem Ezinmegnon, Sophie Borgella, Carine Akplogan, Gilles Cottrell, Stefania Varani, Achille Massougbodji, Kabirou Moutairou, Marita Troye-Blomberg, Philippe Deloron, Adrian J F Luty, Nadine Fievet

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Maternal parasitoses modulate fetal immune development, manifesting as altered cellular immunological activity in cord blood that may be linked to enhanced susceptibility to infections in early life. Plasmodium falciparum typifies such infections, with distinct placental infection-related changes in cord blood exemplified by expanded populations of parasite antigen-specific regulatory T cells. Here we addressed whether such early-onset cellular immunological alterations persist through infancy. Specifically, in order to assess the potential impacts of P. falciparum infections either during pregnancy or during infancy, we quantified lymphocyte subsets in cord blood and in infants' peripheral blood during the first year of life. The principal age-related changes observed, independent of infection status, concerned decreases in the frequencies of CD4+, NKdim and NKT cells, whilst CD8+, Treg and Teff cells' frequencies increased from birth to 12 months of age. P. falciparum infections present at delivery, but not those earlier in gestation, were associated with increased frequencies of Treg and CD8+ T cells but fewer CD4+ and NKT cells during infancy, thus accentuating the observed age-related patterns. Overall, P. falciparum infections arising during infancy were associated with a reversal of the trends associated with maternal infection i.e. with more CD4+ cells, with fewer Treg and CD8+ cells. We conclude that maternal P. falciparum infection at delivery has significant and, in some cases, year-long effects on the composition of infants' peripheral blood lymphocyte populations. Those effects are superimposed on separate and independent age- as well as infant infection-related alterations that, respectively, either match or run counter to them.

Original languageEnglish (US)
Article numbere0139606
JournalPLoS One
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2015
Externally publishedYes

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Lymphocytes
Plasmodium falciparum
Blood
lymphocytes
Mothers
Malaria
blood
Regulatory T-Lymphocytes
Infection
Chemical analysis
Fetal Blood
infection
T-cells
infancy
Natural Killer T-Cells
Eragrostis
Pregnancy
Lymphocyte Subsets
cells
Fetal Development

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum. / Nouatin, Odilon; Gbedande, Komi; Ibitokou, Akanni Adededji Abdoul; Vianou, Bertin; Houngbegnon, Parfait; Ezinmegnon, Sem; Borgella, Sophie; Akplogan, Carine; Cottrell, Gilles; Varani, Stefania; Massougbodji, Achille; Moutairou, Kabirou; Troye-Blomberg, Marita; Deloron, Philippe; Luty, Adrian J F; Fievet, Nadine.

In: PLoS One, Vol. 10, No. 11, e0139606, 01.11.2015.

Research output: Contribution to journalArticle

Nouatin, O, Gbedande, K, Ibitokou, AAA, Vianou, B, Houngbegnon, P, Ezinmegnon, S, Borgella, S, Akplogan, C, Cottrell, G, Varani, S, Massougbodji, A, Moutairou, K, Troye-Blomberg, M, Deloron, P, Luty, AJF & Fievet, N 2015, 'Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum', PLoS One, vol. 10, no. 11, e0139606. https://doi.org/10.1371/journal.pone.0139606
Nouatin, Odilon ; Gbedande, Komi ; Ibitokou, Akanni Adededji Abdoul ; Vianou, Bertin ; Houngbegnon, Parfait ; Ezinmegnon, Sem ; Borgella, Sophie ; Akplogan, Carine ; Cottrell, Gilles ; Varani, Stefania ; Massougbodji, Achille ; Moutairou, Kabirou ; Troye-Blomberg, Marita ; Deloron, Philippe ; Luty, Adrian J F ; Fievet, Nadine. / Infants' peripheral blood lymphocyte composition reflects both maternal and post-natal infection with plasmodium falciparum. In: PLoS One. 2015 ; Vol. 10, No. 11.
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AU - Ezinmegnon, Sem

AU - Borgella, Sophie

AU - Akplogan, Carine

AU - Cottrell, Gilles

AU - Varani, Stefania

AU - Massougbodji, Achille

AU - Moutairou, Kabirou

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