Infection and the role of inflammation in preterm premature rupture of the membranes

Ramkumar Menon, Stephen J. Fortunato

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Spontaneous preterm birth, caused by preterm labor (contractions before 37 weeks' gestation) or preterm premature rupture of the membranes (pPROM) (membrane rupture before the onset of labor) or both account for ∼80% of preterm deliveries. pPROM is associated with 30-40% of preterm deliveries and the incidence of pPROM has increased in the past decade. The question we address here is why some women experience pPROM and some experience preterm labor with no rupture of membranes (ROM) when the etiologic factors associated with both these pathologic complications are the same. To date, studies had evaluated the markers that are commonly elevated in both preterm labor and pPROM. A better understanding of the similarities and differences between the biomolecular pathways leading to each of these conditions may open new avenues for research and intervention. In this chapter we review the role of inflammatory mediators (cytokines and matrix metalloproteinases), and programmed cell death (apoptosis) in preterm labor with no ROM and preterm labor with pPROM to delineate the differences in pathways between the two conditions.

Original languageEnglish
Pages (from-to)467-478
Number of pages12
JournalBest Practice and Research: Clinical Obstetrics and Gynaecology
Volume21
Issue number3
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Premature Obstetric Labor
Inflammation
Infection
Rupture
Membranes
Labor Onset
Premature Birth
Matrix Metalloproteinases
Preterm Premature Rupture of the Membranes
Cell Death
Apoptosis
Cytokines
Pregnancy
Incidence
Research

Keywords

  • apoptosis
  • cytokines
  • genetic associations
  • inflammation
  • MMPs
  • pPROM
  • prematurity

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Infection and the role of inflammation in preterm premature rupture of the membranes. / Menon, Ramkumar; Fortunato, Stephen J.

In: Best Practice and Research: Clinical Obstetrics and Gynaecology, Vol. 21, No. 3, 06.2007, p. 467-478.

Research output: Contribution to journalArticle

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