Infection of genetically immunodeficient mice with Rickettia conorii

N. R. Montenegro, David Walker, B. C. Hegarty

Research output: Contribution to journalArticle

9 Scopus citations


In order to determine the definitive importance of T- and B-lymphocytes in immunity to Rickettsia conorii, mice genetically deficient in T-cells. B-cells, or both T- and B-cells were infected experimentally. T-lymphocytes rather than humoral antibodies were crucial to rikettsial clearance and a reduced mortality rate. Mice incapable of an antibody response to polysaccharide capsular antigens effectively controlled rickettsial infection with no mortality. In contrast, nude mice produced antibody to thymus-independent antigens early in the course of infection, yet experienced severe rickettsial infection resulting in death. The observed hepatic lesions are similar to those of boutonneuse fever. This model offers the opportunity to investigate rickettsial immune mechanisms and hepatic injury.

Original languageEnglish (US)
Pages (from-to)508-514
Number of pages7
JournalActa Virologica
Issue number6
StatePublished - 1984
Externally publishedYes


ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Montenegro, N. R., Walker, D., & Hegarty, B. C. (1984). Infection of genetically immunodeficient mice with Rickettia conorii. Acta Virologica, 28(6), 508-514.