Infection of the endothelium by members of the order Rickettsiales

Gustavo Valbuena, David H. Walker

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

The vascular endothelium is the main target of a limited number of infectious agents; Rickettsia, Ehrlichia ruminantium, and Orientia tsutsugamushi are among them. These arthropod-transmitted obligately-intracellular bacteria cause serious systemic diseases that are not infrequently lethal. In this review, we discuss the bacterial biology, vector biology, and clinical aspects of these con-ditions with particular emphasis on the interactions of these bacteria with the vascular endothelium and how it responds to intracellular infection. The study of these bacteria in relevant in vivo models is likely to offer new insights into the physiology of the endothelium that have not been revealed by other models.

Original languageEnglish (US)
Pages (from-to)1071-1079
Number of pages9
JournalThrombosis and Haemostasis
Volume102
Issue number6
DOIs
StatePublished - Dec 2009

Keywords

  • Blood circulation
  • Ehrlichia ruminantium
  • Endothelium
  • Orientia tsutsugamushi
  • Rickettsia

ASJC Scopus subject areas

  • Hematology

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