Infection with a ratborne hantavirus in us residents is consistently associated with hypertensive renal disease

Gregory E. Glass, Alan J. Watson, James W. LeDuc, Gabor D. Kelen, Thomas C. Quinn, James E. Childs

Research output: Contribution to journalArticle

88 Scopus citations


A survey of 8080 subjects was conducted in Baltimore, examining the association between infection with hantaviruses and renal disease. Two groups (N = 6060) with no known risk factors were selected to establish a baseline antibody prevalence. Overall, antibody prevalence was 0.25%. Seroprevalence increased with age, without sex- or race-related differences. Patients with proteinuria showed the same patterns of infection but were more commonly seropositive (1.46%) than the reference group (OR, 3.23; P <.05). Infection among dialysis patients with end-stage renal disease was 2.76%, significantly higher than in the reference group (OR, 5.03; P <.05). In the proteinuria and the dialysis groups, hantavirus infection was consistently associated with a diagnosis of hypertensive renal disease. The association was unrelated to other chronic renal disease diagnoses. Overall, 6.5% of patients with end-stage renal disease due to hypertension were seropositive for a hantavirus. These data suggest that hantavirus infection is associated with hypertensive renal disease.

Original languageEnglish (US)
Pages (from-to)614-620
Number of pages7
JournalJournal of Infectious Diseases
Issue number3
StatePublished - Mar 1993
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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