Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease

Gregory E. Glass, Alan J. Watson, James LeDuc, Gabor D. Kelen, Thomas C. Quinn, James E. Childs

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

A survey of 8080 subjects was conducted in Baltimore, examining the association between infection with hantaviruses and renal disease. Two groups (N = 6060) with no known risk factors were selected to establish a baseline antibody prevalence. Overall, antibody prevalence was 0.25%. Seroprevalence increased with age, without sex- or race-related differences. Patients with proteinuria showed the same patterns of infection but were more commonly seropositive (1.46%) than the reference group (OR, 3.23; P < .05). Infection among dialysis patients with end-stage renal disease was 2.76%, significantly higher than in the reference group (OR, 5.03; P < .05). In the proteinuria and the dialysis groups, hantavirus infection was consistently associated with a diagnosis of hypertensive renal disease. The association was unrelated to other chronic renal disease diagnoses. Overall, 6.5% of patients with end-stage renal disease due to hypertension were seropositive for a hantavirus. These data suggest that hantavirus infection is associated with hypertensive renal disease.

Original languageEnglish (US)
Pages (from-to)614-620
Number of pages7
JournalJournal of Infectious Diseases
Volume167
Issue number3
StatePublished - Mar 1993
Externally publishedYes

Fingerprint

Hantavirus Infections
Hantavirus
Kidney
Proteinuria
Chronic Kidney Failure
Dialysis
Infection
Baltimore
Antibodies
Seroepidemiologic Studies
Chronic Renal Insufficiency
Hypertension

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Glass, G. E., Watson, A. J., LeDuc, J., Kelen, G. D., Quinn, T. C., & Childs, J. E. (1993). Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease. Journal of Infectious Diseases, 167(3), 614-620.

Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease. / Glass, Gregory E.; Watson, Alan J.; LeDuc, James; Kelen, Gabor D.; Quinn, Thomas C.; Childs, James E.

In: Journal of Infectious Diseases, Vol. 167, No. 3, 03.1993, p. 614-620.

Research output: Contribution to journalArticle

Glass, Gregory E. ; Watson, Alan J. ; LeDuc, James ; Kelen, Gabor D. ; Quinn, Thomas C. ; Childs, James E. / Infection with a ratborne hantavirus in US residents is consistently associated with hypertensive renal disease. In: Journal of Infectious Diseases. 1993 ; Vol. 167, No. 3. pp. 614-620.
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