Infections Related to Development of Head and Neck Cancers

Orly M. Coblens, Jason G. Newman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Worldwide, over 550,000 new cases of head and neck cancer are diagnosed each year. Of those, approximately 119,000 are diagnosed in the United States. Head and neck cancers are predominately squamous cell carcinoma of the tongue, pharynx and larynx but they can also be other types of cancers that arise within the nasal cavity, sinuses, lips, mouth, thyroid gland, skin, salivary glands and ears. These cancers often present at an advanced stage (III or IV) and require multimodal therapy with a combination of surgery, radiation and/or chemotherapy. Alcohol and smoking are established risk factors for these cancers that increase risk independently (with tobacco exposure conveying a higher risk) and synergistically. Other important causes of head and neck cancers are infectious microbes, including but not limited to human papilloma virus (HPV), Epstein-Barr virus (EBV), and Merkel Cell Polyomavirus. The majority of this chapter will cover HPV and its implication for the development of head and neck squamous cell carcinoma (SCC), especially within the oropharynx.

Original languageEnglish (US)
Title of host publicationCurrent Cancer Research
PublisherSpringer Nature
Pages185-203
Number of pages19
DOIs
StatePublished - 2019
Externally publishedYes

Publication series

NameCurrent Cancer Research
ISSN (Print)2199-2584
ISSN (Electronic)2199-2592

Keywords

  • EBV
  • HPV
  • Head and neck cancer
  • Oropharyngeal carcinoma
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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