TY - JOUR
T1 - Infectious etiology and amyloidosis in Alzheimer's disease
T2 - The puzzle continues
AU - Kayed, Rakez
N1 - Publisher Copyright:
© 2021 THE AUTHOR.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Recent studies have renewed the debate on infectious etiology in late-onset Alzheimer's disease. Bocharova et al. reported that abundant expression of human beta amyloid (Aβ) in the mouse brain (5XFAD animals) failed to protect against acute herpes simplex virus type 1 infection relative to control mice. While this study does not confirm the antiviral actions of Aβ, it neither supports nor disproves the hypothesis that infection with microbial pathogens is the major cause of Alzheimer's disease.
AB - Recent studies have renewed the debate on infectious etiology in late-onset Alzheimer's disease. Bocharova et al. reported that abundant expression of human beta amyloid (Aβ) in the mouse brain (5XFAD animals) failed to protect against acute herpes simplex virus type 1 infection relative to control mice. While this study does not confirm the antiviral actions of Aβ, it neither supports nor disproves the hypothesis that infection with microbial pathogens is the major cause of Alzheimer's disease.
UR - http://www.scopus.com/inward/record.url?scp=85110600372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85110600372&partnerID=8YFLogxK
U2 - 10.1016/j.jbc.2021.100936
DO - 10.1016/j.jbc.2021.100936
M3 - Article
C2 - 34217702
AN - SCOPUS:85110600372
SN - 0021-9258
VL - 297
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 2
M1 - 100936
ER -