Infiltrating syringomatous adenoma of the nipple. A clinical and pathological study of 11 cases

M. W. Jones, H. J. Norris, Russell Snyder

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The clinical and pathologic findings of 11 infiltrating syringomatous adenomas of the nipple (ISA) were studied. All neoplasms were composed of small ducts and solid strands of epithelial cells surrounded by desmoplastic stroma. Ten of the 11 invaded the smooth muscle of the nipple, four extended to underlying breast tissue, and one showed perineural invasion. All lesions had an infiltrative margin, but 10 were treated successfully by local excision, even though five (45%) recurred. None metastasized. ISA must be distinguished from nipple duct adenoma and tubular carcinoma. Its clinical significance lies primarily in its recognition as a distinctive benign neoplasm. In the past, a variety of terms have been used to describe this lesion, whether it occurred in the skin, nipple, or substance of the breast. 'Infiltrating syringomatous adenoma' is the preferred term to avoid using 'carcinoma' for lesions involving the breast.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume13
Issue number3
StatePublished - 1989
Externally publishedYes

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Nipples
Adenoma
Breast
Smooth Muscle
Neoplasms
Adenocarcinoma
Epithelial Cells
Clinical Studies
Carcinoma
Skin

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Infiltrating syringomatous adenoma of the nipple. A clinical and pathological study of 11 cases. / Jones, M. W.; Norris, H. J.; Snyder, Russell.

In: American Journal of Surgical Pathology, Vol. 13, No. 3, 1989, p. 197-201.

Research output: Contribution to journalArticle

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