Inflammatory consequences in a rodent model of mild traumatic brain injury

J. Regino Perez-Polo, Harriet C. Rea, Kathia M. Johnson, Margaret A. Parsley, Geda C. Unabia, GuoJing Xu, Smitha K. Infante, Douglas Dewitt, Claire E. Hulsebosch

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences to mTBI that persist over time and, in part, are responsible for resultant pathogenesis and clinical outcomes. We used an adaptation (1 atmosphere pressure) of a well-characterized moderate-to-severe brain lateral fluid percussion (LFP) brain injury rat model. Our mild LFP injury resulted in acute increases in interleukin-1α/β and tumor necrosis factor alpha levels, macrophage/microglial and astrocytic activation, evidence of heightened cellular stress, and blood-brain barrier (BBB) dysfunction that were evident as early as 3-6 h postinjury. Both glial activation and BBB dysfunction persisted for 18 days postinjury.

Original languageEnglish (US)
Pages (from-to)727-740
Number of pages14
JournalJournal of Neurotrauma
Volume30
Issue number9
DOIs
StatePublished - May 1 2013

Fingerprint

Brain Concussion
Percussion
Blood-Brain Barrier
Rodentia
Blast Injuries
Athletic Injuries
Brain
Atmosphere
Interleukin-1
Neuroglia
Brain Injuries
Cognition
Tumor Necrosis Factor-alpha
Macrophages
Pressure
Equipment and Supplies
Wounds and Injuries

Keywords

  • Astrocytes
  • Blood-brain barrier
  • Cytokines
  • Inflammation
  • Mild traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G., ... Hulsebosch, C. E. (2013). Inflammatory consequences in a rodent model of mild traumatic brain injury. Journal of Neurotrauma, 30(9), 727-740. https://doi.org/10.1089/neu.2012.2650

Inflammatory consequences in a rodent model of mild traumatic brain injury. / Perez-Polo, J. Regino; Rea, Harriet C.; Johnson, Kathia M.; Parsley, Margaret A.; Unabia, Geda C.; Xu, GuoJing; Infante, Smitha K.; Dewitt, Douglas; Hulsebosch, Claire E.

In: Journal of Neurotrauma, Vol. 30, No. 9, 01.05.2013, p. 727-740.

Research output: Contribution to journalArticle

Perez-Polo, JR, Rea, HC, Johnson, KM, Parsley, MA, Unabia, GC, Xu, G, Infante, SK, Dewitt, D & Hulsebosch, CE 2013, 'Inflammatory consequences in a rodent model of mild traumatic brain injury', Journal of Neurotrauma, vol. 30, no. 9, pp. 727-740. https://doi.org/10.1089/neu.2012.2650
Perez-Polo JR, Rea HC, Johnson KM, Parsley MA, Unabia GC, Xu G et al. Inflammatory consequences in a rodent model of mild traumatic brain injury. Journal of Neurotrauma. 2013 May 1;30(9):727-740. https://doi.org/10.1089/neu.2012.2650
Perez-Polo, J. Regino ; Rea, Harriet C. ; Johnson, Kathia M. ; Parsley, Margaret A. ; Unabia, Geda C. ; Xu, GuoJing ; Infante, Smitha K. ; Dewitt, Douglas ; Hulsebosch, Claire E. / Inflammatory consequences in a rodent model of mild traumatic brain injury. In: Journal of Neurotrauma. 2013 ; Vol. 30, No. 9. pp. 727-740.
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