Inflammatory consequences in a rodent model of mild traumatic brain injury

J. Regino Perez-Polo, Harriet C. Rea, Kathia M. Johnson, Margaret A. Parsley, Geda C. Unabia, Guo Jing Xu, Smitha K. Infante, Douglas S. Dewitt, Claire E. Hulsebosch

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

Mild traumatic brain injury (mTBI), particularly mild "blast type" injuries resulting from improvised exploding devices and many sport-caused injuries to the brain, result in long-term impairment of cognition and behavior. Our central hypothesis is that there are inflammatory consequences to mTBI that persist over time and, in part, are responsible for resultant pathogenesis and clinical outcomes. We used an adaptation (1 atmosphere pressure) of a well-characterized moderate-to-severe brain lateral fluid percussion (LFP) brain injury rat model. Our mild LFP injury resulted in acute increases in interleukin-1α/β and tumor necrosis factor alpha levels, macrophage/microglial and astrocytic activation, evidence of heightened cellular stress, and blood-brain barrier (BBB) dysfunction that were evident as early as 3-6 h postinjury. Both glial activation and BBB dysfunction persisted for 18 days postinjury.

Original languageEnglish (US)
Pages (from-to)727-740
Number of pages14
JournalJournal of neurotrauma
Volume30
Issue number9
DOIs
StatePublished - May 1 2013

Keywords

  • Astrocytes
  • Blood-brain barrier
  • Cytokines
  • Inflammation
  • Mild traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

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    Perez-Polo, J. R., Rea, H. C., Johnson, K. M., Parsley, M. A., Unabia, G. C., Xu, G. J., Infante, S. K., Dewitt, D. S., & Hulsebosch, C. E. (2013). Inflammatory consequences in a rodent model of mild traumatic brain injury. Journal of neurotrauma, 30(9), 727-740. https://doi.org/10.1089/neu.2012.2650