Inflammatory markers are elevated in overweight Mexican-American children

Brian K. McFarlin, Craig A. Johnston, Chermaine Tyler, Alexander T. Hutchison, Michael L. Kueht, Rebecca Reeves, John P. Foreyt

Research output: Contribution to journalArticle

25 Scopus citations


Objective. The purpose of the present study was to determine the effect of body weight on blood lipid profile, insulin resistance and inflammatory biomarkers in Mexican-American children. Methods. Children (13.3 ± 0.1 year) were recruited from a local school and assigned to one of three groups as a volunteer sample: healthy weight (HW) (≥10th and <85th BMI percentile; n = 42), at risk of overweight (RO) (≥85th and ≥95th; n = 25) or overweight (OW) (≥95th; n = 42). Plasma concentrations of hsCRP, sCD14, sIL-6R, sTNF-αR1, sTNF-αR2, IL-6 and TNF-α were determined by ELISA. Results. OW children had significantly greater plasma concentrations of hsCRP (P = 0.003), sCD14 (P = 0.013), sIL-6R (P = 0.010), sTNF-αR1 (P < 0.001), sTNF-αR2 (P = 0.005), insulin (P = 0.001), TC:HDL ratio (P < 0.001) and triglycerides (P < 0.001) than HW children. Also plasma concentrations of hsCRP, sIL-6R and sTNF-αR1 were significantly greater in OW compared with RO children. Conclusion. Overweight Mexican-American children had a higher concentration of inflammatory biomarkers than healthy weight children. To our knowledge, this is the first study to report that sCD14 is elevated in overweight compared with healthy weight Mexican-American children.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalInternational Journal of Pediatric Obesity
Issue number4
StatePublished - Nov 29 2007
Externally publishedYes


  • Adiposity
  • C-reactive protein
  • IL-6
  • IL-6R
  • sCD14
  • sTNF-αR1
  • sTNF-αR2
  • TNF-α

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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    McFarlin, B. K., Johnston, C. A., Tyler, C., Hutchison, A. T., Kueht, M. L., Reeves, R., & Foreyt, J. P. (2007). Inflammatory markers are elevated in overweight Mexican-American children. International Journal of Pediatric Obesity, 2(4), 235-241.