Infliximab in the treatment of ulcerative colitis with toxic megacolon

Parupudi V.J. Sriram, K. S.Pavan Reddy, Guduru V. Rao, Darisetty Santosh, Duvvuru Nageshwar Reddy

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Toxic megacolon is a gastrointestinal emergency requiring prompt management to avoid fatal outcome. Although a majority of patients respond to conservative treatment, those not responding have been treated with intravenous cyclosporine or emergency surgery. Infliximab has been tried in patients with severe steroid-refractory ulcerative colitis. We report the successful use of this drug in the management of toxic megacolon in a 48-year-old woman not responding to the routine measures and who refused surgery.

Original languageEnglish (US)
Pages (from-to)22-23
Number of pages2
JournalIndian Journal of Gastroenterology
Issue number1
StatePublished - Jan 2004
Externally publishedYes


  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Infliximab in the treatment of ulcerative colitis with toxic megacolon'. Together they form a unique fingerprint.

Cite this