Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption, and serum electrolytes, corticosterone, and renin activity

C. E. Hall, C. E. Gomez-Sanchez, O. B. Holland, [No Value] NassethD.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Young, unilaterally nephrectomized, female Sprague-Dawley rats were given daily sc injections of 19-nordeoxycorticosterone acetate (19-nor-DOCA) in oil at a dosage of 100 μg/day for 21 days and twice that amount for a further 11 days. One group drank distilled water and another drank 1% NaCl solution. Comparable control groups received oil injections. Another group received DOCA at the same steroid dosage and drank saline. Both 19-nor-DOCA-treated groups rapidly became hypertensive and developed cardiac hypertrophy, as did those given DOCA and saline. Saline consumption was greater in rats receiving 19-nor-DOCA, than in those given DOCA. Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration. Plasma sodium concentration was not affected by any form of treatment. Clearly, 19-nor-DOCA is a potent mineralocorticoid and hypertensogenic agent. Since the parent steroid is knwon to be present abundantly in the urine of rats with regenerating adrenal glands, although circulating amounts have not yet been ascertained in that circumstance, it may be etiologically involved in adrenal regeneration hypertension, which such rats are prone to develop.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalEndocrinology
Volume105
Issue number3
StatePublished - 1979

Fingerprint

Desoxycorticosterone Acetate
Desoxycorticosterone
Corticosterone
Renin
Electrolytes
Blood Pressure
Serum
Oils
Steroids
Mineralocorticoids
Injections
Hypokalemia
Water
Cardiomegaly
Adrenal Glands
Thymus Gland
Sprague Dawley Rats
Regeneration
Acetates
Sodium

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption, and serum electrolytes, corticosterone, and renin activity. / Hall, C. E.; Gomez-Sanchez, C. E.; Holland, O. B.; NassethD., [No Value].

In: Endocrinology, Vol. 105, No. 3, 1979, p. 600-604.

Research output: Contribution to journalArticle

Hall, C. E. ; Gomez-Sanchez, C. E. ; Holland, O. B. ; NassethD., [No Value]. / Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption, and serum electrolytes, corticosterone, and renin activity. In: Endocrinology. 1979 ; Vol. 105, No. 3. pp. 600-604.
@article{25ac9cda04344de4b32e123a3634f2d7,
title = "Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption, and serum electrolytes, corticosterone, and renin activity",
abstract = "Young, unilaterally nephrectomized, female Sprague-Dawley rats were given daily sc injections of 19-nordeoxycorticosterone acetate (19-nor-DOCA) in oil at a dosage of 100 μg/day for 21 days and twice that amount for a further 11 days. One group drank distilled water and another drank 1{\%} NaCl solution. Comparable control groups received oil injections. Another group received DOCA at the same steroid dosage and drank saline. Both 19-nor-DOCA-treated groups rapidly became hypertensive and developed cardiac hypertrophy, as did those given DOCA and saline. Saline consumption was greater in rats receiving 19-nor-DOCA, than in those given DOCA. Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration. Plasma sodium concentration was not affected by any form of treatment. Clearly, 19-nor-DOCA is a potent mineralocorticoid and hypertensogenic agent. Since the parent steroid is knwon to be present abundantly in the urine of rats with regenerating adrenal glands, although circulating amounts have not yet been ascertained in that circumstance, it may be etiologically involved in adrenal regeneration hypertension, which such rats are prone to develop.",
author = "Hall, {C. E.} and Gomez-Sanchez, {C. E.} and Holland, {O. B.} and NassethD., {[No Value]}",
year = "1979",
language = "English (US)",
volume = "105",
pages = "600--604",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "3",

}

TY - JOUR

T1 - Influence of 19-nor-deoxycorticosterone on blood pressure, saline consumption, and serum electrolytes, corticosterone, and renin activity

AU - Hall, C. E.

AU - Gomez-Sanchez, C. E.

AU - Holland, O. B.

AU - NassethD., [No Value]

PY - 1979

Y1 - 1979

N2 - Young, unilaterally nephrectomized, female Sprague-Dawley rats were given daily sc injections of 19-nordeoxycorticosterone acetate (19-nor-DOCA) in oil at a dosage of 100 μg/day for 21 days and twice that amount for a further 11 days. One group drank distilled water and another drank 1% NaCl solution. Comparable control groups received oil injections. Another group received DOCA at the same steroid dosage and drank saline. Both 19-nor-DOCA-treated groups rapidly became hypertensive and developed cardiac hypertrophy, as did those given DOCA and saline. Saline consumption was greater in rats receiving 19-nor-DOCA, than in those given DOCA. Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration. Plasma sodium concentration was not affected by any form of treatment. Clearly, 19-nor-DOCA is a potent mineralocorticoid and hypertensogenic agent. Since the parent steroid is knwon to be present abundantly in the urine of rats with regenerating adrenal glands, although circulating amounts have not yet been ascertained in that circumstance, it may be etiologically involved in adrenal regeneration hypertension, which such rats are prone to develop.

AB - Young, unilaterally nephrectomized, female Sprague-Dawley rats were given daily sc injections of 19-nordeoxycorticosterone acetate (19-nor-DOCA) in oil at a dosage of 100 μg/day for 21 days and twice that amount for a further 11 days. One group drank distilled water and another drank 1% NaCl solution. Comparable control groups received oil injections. Another group received DOCA at the same steroid dosage and drank saline. Both 19-nor-DOCA-treated groups rapidly became hypertensive and developed cardiac hypertrophy, as did those given DOCA and saline. Saline consumption was greater in rats receiving 19-nor-DOCA, than in those given DOCA. Rats injected with 19-nor-DOCA and given water to drink showed enhanced growth and developed thymus enlargement and displayed hypokalemia and a reduction in both serum renin activity and corticosterone concentration. Plasma sodium concentration was not affected by any form of treatment. Clearly, 19-nor-DOCA is a potent mineralocorticoid and hypertensogenic agent. Since the parent steroid is knwon to be present abundantly in the urine of rats with regenerating adrenal glands, although circulating amounts have not yet been ascertained in that circumstance, it may be etiologically involved in adrenal regeneration hypertension, which such rats are prone to develop.

UR - http://www.scopus.com/inward/record.url?scp=0018646976&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018646976&partnerID=8YFLogxK

M3 - Article

C2 - 157270

AN - SCOPUS:0018646976

VL - 105

SP - 600

EP - 604

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 3

ER -