Influence of detergent aerosol on lung microvascular permeability

C. Z. Wang, R. E. Barrow, C. S. Cox, S. F. Yang, David Herndon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Noncardiogenic edema fluid often contains high levels of plasma proteins, which may inhibit the function of the lung surfactant complex and thus decrease interstitial hydrostatic pressures. We questioned whether, in the awake and standing animal, displacement of the alveolar surface lining would alter the permeability of the thin and sparsely supported pulmonary capillaries. Sheep prepared with lung lymph-fistulae were given an aerosolized detergent (Det) to displace the lung surfactant complex. After the sheep were given Det, protein flux was significantly increased (P < 0.05). To validate the suggested permeability increase, pulmonary vein occluders were surgically implanted and experiments repeated with pulmonary arterial pressures elevated 10 mmHg above baseline. After 2 h of elevated pulmonary arterial pressure, lung lymph increased fivefold. At this time, lymph-to-plasma total protein concentration ratios for air and saline-plus- ethanol vehicle were significantly lower (P < 0.01) than baseline ratios (0.26 ± 0.06 and 0.34 ± 0.07, respectively). No significant difference could be shown in lymph-to-plasma ratios after the sheep were given Det. We conclude that disruption of the alveolar lining can cause a detectable increase in protein flux due, in part, to an increase in microvascular permeability.

Original languageEnglish (US)
Pages (from-to)1016-1023
Number of pages8
JournalJournal of Applied Physiology
Volume74
Issue number3
StatePublished - 1993

Fingerprint

Capillary Permeability
Aerosols
Detergents
Lung
Lymph
Sheep
Surface-Active Agents
Blood Proteins
Permeability
Arterial Pressure
Hydrostatic Pressure
Pulmonary Veins
Fistula
Edema
Proteins
Ethanol
Air

Keywords

  • alveolar surface tension
  • lung lymph flow
  • lung water
  • lymph-to-plasma barrier
  • protein flux
  • pulmonary edema

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Wang, C. Z., Barrow, R. E., Cox, C. S., Yang, S. F., & Herndon, D. (1993). Influence of detergent aerosol on lung microvascular permeability. Journal of Applied Physiology, 74(3), 1016-1023.

Influence of detergent aerosol on lung microvascular permeability. / Wang, C. Z.; Barrow, R. E.; Cox, C. S.; Yang, S. F.; Herndon, David.

In: Journal of Applied Physiology, Vol. 74, No. 3, 1993, p. 1016-1023.

Research output: Contribution to journalArticle

Wang, CZ, Barrow, RE, Cox, CS, Yang, SF & Herndon, D 1993, 'Influence of detergent aerosol on lung microvascular permeability', Journal of Applied Physiology, vol. 74, no. 3, pp. 1016-1023.
Wang CZ, Barrow RE, Cox CS, Yang SF, Herndon D. Influence of detergent aerosol on lung microvascular permeability. Journal of Applied Physiology. 1993;74(3):1016-1023.
Wang, C. Z. ; Barrow, R. E. ; Cox, C. S. ; Yang, S. F. ; Herndon, David. / Influence of detergent aerosol on lung microvascular permeability. In: Journal of Applied Physiology. 1993 ; Vol. 74, No. 3. pp. 1016-1023.
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