Influence of different anesthetic agents on the release of cholecystokinin in dogs

P. Lilja, I. Wiener, K. Inoue, L. L. Priano, G. H. Greeley, J. C. Thompson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study was to investigate the effect of pentobarbital, halothane, and chloralose anesthesia on the endogenous release of cholecystokinin-33 (CCK-33) in dogs prepared with duodenal fistulas. Release of CCK-33 was induced by intraduodenal infusion of a medium-chain triglyceride (corn oil, 1 gm/kg/hr). Plasma CCK-33 concentrations were measured by means of a specific radioimmunoassay. Pentobarbital and chloralose were administered intravenously, and halothane was administered by a vaporizer (semiclosed technique), with O2 and N2O used as barriers. No incidence of hypotension was found with the use of these anesthetic agents. Basal concentrations of plasma CCK-33 were elevated, although not significantly, during pentobarbital or chloralose anesthesia. In conscious dogs (control study), peak plasma CCK-33 concentrations of 529 ± 53 pg/ml were measured 30 minutes after intraduodenal infusion of fat. Under pentobarbital anesthesia, peak plasma CCK-33 concentrations of 452 ± 264 pg/ml were found 80 minutes after infusion of fat. Under halothane anesthesia, fat-induced release of CCK-33 was abolished, whereas chloralose anesthesia did not influence fat-induced release of CCK-33. These findings may have implications for the design of future studies of gastrointestinal physiology. In CCK-33 studies that require anesthesia, chloralose appears to be an appropriate anesthetic agent.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalSurgery
Volume97
Issue number4
StatePublished - 1985

Fingerprint

Cholecystokinin
Anesthetics
Dogs
Chloralose
Anesthesia
Pentobarbital
Halothane
Fats
Corn Oil
Nebulizers and Vaporizers
Hypotension
Fistula
Radioimmunoassay
Triglycerides
Incidence

ASJC Scopus subject areas

  • Surgery

Cite this

Lilja, P., Wiener, I., Inoue, K., Priano, L. L., Greeley, G. H., & Thompson, J. C. (1985). Influence of different anesthetic agents on the release of cholecystokinin in dogs. Surgery, 97(4), 415-419.

Influence of different anesthetic agents on the release of cholecystokinin in dogs. / Lilja, P.; Wiener, I.; Inoue, K.; Priano, L. L.; Greeley, G. H.; Thompson, J. C.

In: Surgery, Vol. 97, No. 4, 1985, p. 415-419.

Research output: Contribution to journalArticle

Lilja, P, Wiener, I, Inoue, K, Priano, LL, Greeley, GH & Thompson, JC 1985, 'Influence of different anesthetic agents on the release of cholecystokinin in dogs', Surgery, vol. 97, no. 4, pp. 415-419.
Lilja P, Wiener I, Inoue K, Priano LL, Greeley GH, Thompson JC. Influence of different anesthetic agents on the release of cholecystokinin in dogs. Surgery. 1985;97(4):415-419.
Lilja, P. ; Wiener, I. ; Inoue, K. ; Priano, L. L. ; Greeley, G. H. ; Thompson, J. C. / Influence of different anesthetic agents on the release of cholecystokinin in dogs. In: Surgery. 1985 ; Vol. 97, No. 4. pp. 415-419.
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