Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors

Is There a Relationship?

Leslie R. Halpern, Malcolm L. Shealer, Rian Cho, Elizabeth B. McMichael, Joseph Rogers, Daphne Ferguson-Young, Charles Mouton, Mohammad Tabatabai, Janet Southerland, Pandu Gangula

Research output: Contribution to journalArticle

Abstract

Background/purpose: Intimate partner violence (IPV) is a global public health epidemic that initiates/exacerbates health consequences affecting a victim's lifespan. IPV can significantly predispose women to a lifetime risk of developing cardiovascular disease (CVD) due to the effects of stress and inflammation. This study investigates the correlation among IPV exposure, in-vivo CVD events, and inflammatory biomarkers as predictor indices(s) for CVD in female dental patients. Methods: Of 37 women enrolled in this study, 19 were African-American (AA) and 18 non-African-American (non-AA) and their ages ranged from 19 to 63 years. IPV-exposure and stress-induced in-vivo CVD events such as Chest Pain (CP) and Heart palpitations were recorded from all enrolled subjects. Cardiovascular events were obtained through surveys by patient self-report. Saliva specimens were obtained from all women and were analyzed for CVD biomarkers using multiplex-ELISA. Results: The prevalence of IPV was 51% (19/37) and statistically equivalent for AA and non-AA. The results show differences in experience of 1) CP (p < 0.01) and 2) heart palpitations (p < 0.02) when IPV + participants are compared with IPV- AA and non-AA cohorts. Of 10 CVD biomarkers analyzed, significant correlations between IPV+ and IPV- subjects were observed for biomarkers that include Interleukin-1β/sCD40L; TNFα/sCD40L; Myoglobin/IL-1β; CRP/sCD40L; CRP/IL-6; CRP/TNFα; TNFα/siCAM; CRP/MMP9; TNF-α/Adiponectin (p < 0.01). Discussion/Implications: Analysis of in vivo CVD status showed that significant race/health disparities exist in IPV + cohorts, as well as increased expression of inflammatory mediators, specifically CRP, IL-1β, IL-6, MMP9. Women who have experienced IPV may be a target cohort for primary prevention of CVD. The use of salivary biomarkers and our protocol may provide a less invasive method to help increase identification of victims at risk for IPV and CVD and potentially decrease other health injuries associated with IPV exposure.

Original languageEnglish (US)
JournalJournal of the National Medical Association
DOIs
StateAccepted/In press - 2017

Fingerprint

Biosensing Techniques
Cardiovascular Diseases
Biomarkers
Interleukin-1
African Americans
Chest Pain
Intimate Partner Violence
Exposure to Violence
Interleukin-6
Health
Myoglobin
Adiponectin
Primary Prevention
Saliva
Self Report
Tooth
Public Health
Enzyme-Linked Immunosorbent Assay

Keywords

  • Cardiovascular disease (CVD)
  • Facial injuries
  • Health disparities
  • Intimate partner violence (IPV)
  • Questionnaires
  • Saliva

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors : Is There a Relationship? / Halpern, Leslie R.; Shealer, Malcolm L.; Cho, Rian; McMichael, Elizabeth B.; Rogers, Joseph; Ferguson-Young, Daphne; Mouton, Charles; Tabatabai, Mohammad; Southerland, Janet; Gangula, Pandu.

In: Journal of the National Medical Association, 2017.

Research output: Contribution to journalArticle

Halpern, Leslie R. ; Shealer, Malcolm L. ; Cho, Rian ; McMichael, Elizabeth B. ; Rogers, Joseph ; Ferguson-Young, Daphne ; Mouton, Charles ; Tabatabai, Mohammad ; Southerland, Janet ; Gangula, Pandu. / Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors : Is There a Relationship?. In: Journal of the National Medical Association. 2017.
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title = "Influence of Intimate Partner Violence (IPV) Exposure on Cardiovascular and Salivary Biosensors: Is There a Relationship?",
abstract = "Background/purpose: Intimate partner violence (IPV) is a global public health epidemic that initiates/exacerbates health consequences affecting a victim's lifespan. IPV can significantly predispose women to a lifetime risk of developing cardiovascular disease (CVD) due to the effects of stress and inflammation. This study investigates the correlation among IPV exposure, in-vivo CVD events, and inflammatory biomarkers as predictor indices(s) for CVD in female dental patients. Methods: Of 37 women enrolled in this study, 19 were African-American (AA) and 18 non-African-American (non-AA) and their ages ranged from 19 to 63 years. IPV-exposure and stress-induced in-vivo CVD events such as Chest Pain (CP) and Heart palpitations were recorded from all enrolled subjects. Cardiovascular events were obtained through surveys by patient self-report. Saliva specimens were obtained from all women and were analyzed for CVD biomarkers using multiplex-ELISA. Results: The prevalence of IPV was 51{\%} (19/37) and statistically equivalent for AA and non-AA. The results show differences in experience of 1) CP (p < 0.01) and 2) heart palpitations (p < 0.02) when IPV + participants are compared with IPV- AA and non-AA cohorts. Of 10 CVD biomarkers analyzed, significant correlations between IPV+ and IPV- subjects were observed for biomarkers that include Interleukin-1β/sCD40L; TNFα/sCD40L; Myoglobin/IL-1β; CRP/sCD40L; CRP/IL-6; CRP/TNFα; TNFα/siCAM; CRP/MMP9; TNF-α/Adiponectin (p < 0.01). Discussion/Implications: Analysis of in vivo CVD status showed that significant race/health disparities exist in IPV + cohorts, as well as increased expression of inflammatory mediators, specifically CRP, IL-1β, IL-6, MMP9. Women who have experienced IPV may be a target cohort for primary prevention of CVD. The use of salivary biomarkers and our protocol may provide a less invasive method to help increase identification of victims at risk for IPV and CVD and potentially decrease other health injuries associated with IPV exposure.",
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T2 - Is There a Relationship?

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AU - Shealer, Malcolm L.

AU - Cho, Rian

AU - McMichael, Elizabeth B.

AU - Rogers, Joseph

AU - Ferguson-Young, Daphne

AU - Mouton, Charles

AU - Tabatabai, Mohammad

AU - Southerland, Janet

AU - Gangula, Pandu

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N2 - Background/purpose: Intimate partner violence (IPV) is a global public health epidemic that initiates/exacerbates health consequences affecting a victim's lifespan. IPV can significantly predispose women to a lifetime risk of developing cardiovascular disease (CVD) due to the effects of stress and inflammation. This study investigates the correlation among IPV exposure, in-vivo CVD events, and inflammatory biomarkers as predictor indices(s) for CVD in female dental patients. Methods: Of 37 women enrolled in this study, 19 were African-American (AA) and 18 non-African-American (non-AA) and their ages ranged from 19 to 63 years. IPV-exposure and stress-induced in-vivo CVD events such as Chest Pain (CP) and Heart palpitations were recorded from all enrolled subjects. Cardiovascular events were obtained through surveys by patient self-report. Saliva specimens were obtained from all women and were analyzed for CVD biomarkers using multiplex-ELISA. Results: The prevalence of IPV was 51% (19/37) and statistically equivalent for AA and non-AA. The results show differences in experience of 1) CP (p < 0.01) and 2) heart palpitations (p < 0.02) when IPV + participants are compared with IPV- AA and non-AA cohorts. Of 10 CVD biomarkers analyzed, significant correlations between IPV+ and IPV- subjects were observed for biomarkers that include Interleukin-1β/sCD40L; TNFα/sCD40L; Myoglobin/IL-1β; CRP/sCD40L; CRP/IL-6; CRP/TNFα; TNFα/siCAM; CRP/MMP9; TNF-α/Adiponectin (p < 0.01). Discussion/Implications: Analysis of in vivo CVD status showed that significant race/health disparities exist in IPV + cohorts, as well as increased expression of inflammatory mediators, specifically CRP, IL-1β, IL-6, MMP9. Women who have experienced IPV may be a target cohort for primary prevention of CVD. The use of salivary biomarkers and our protocol may provide a less invasive method to help increase identification of victims at risk for IPV and CVD and potentially decrease other health injuries associated with IPV exposure.

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