The influence of formaldehyde on bile secretion and tissue glutathione concentrations was investigated in male Sprague Dawley rats following a sublethal intraperitoneal administration (72 mg/kg). Within 2-3 h of administration formaldehyde caused a 2-fold increase in secretion of bile and significant decrease in the levels of glutathione in liver (39% of control) followed by kidney (33%), lung (31%) and brain (22%). The results indicate a possible protective role of glutathione in the toxicity of formaldehyde.
|Original language||English (US)|
|Number of pages||4|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - Dec 1 1986|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)