Influence of intraperitoneally administered formaldehyde on bile production and tissue glutathione levels in rats

M. Y.H. Farooqui, R. K. Upreti, A. E. Ahmed, G. A.S. Ansari

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The influence of formaldehyde on bile secretion and tissue glutathione concentrations was investigated in male Sprague Dawley rats following a sublethal intraperitoneal administration (72 mg/kg). Within 2-3 h of administration formaldehyde caused a 2-fold increase in secretion of bile and significant decrease in the levels of glutathione in liver (39% of control) followed by kidney (33%), lung (31%) and brain (22%). The results indicate a possible protective role of glutathione in the toxicity of formaldehyde.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume53
Issue number2
StatePublished - Dec 1 1986

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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