Influence of intraperitoneally administered formaldehyde on bile production and tissue glutathione levels in rats

M. Y H Farooqui, R. K. Upreti, A. E. Ahmed, Ghulam Ansari

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The influence of formaldehyde on bile secretion and tissue glutathione concentrations was investigated in male Sprague Dawley rats following a sublethal intraperitoneal administration (72 mg/kg). Within 2-3 h of administration formaldehyde caused a 2-fold increase in secretion of bile and significant decrease in the levels of glutathione in liver (39% of control) followed by kidney (33%), lung (31%) and brain (22%). The results indicate a possible protective role of glutathione in the toxicity of formaldehyde.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume53
Issue number2
StatePublished - 1986

Fingerprint

Bile
Formaldehyde
Glutathione
Rats
Tissue
Liver
Sprague Dawley Rats
Toxicity
Brain
Kidney
Lung
Formaldehyde poisoning

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Influence of intraperitoneally administered formaldehyde on bile production and tissue glutathione levels in rats. / Farooqui, M. Y H; Upreti, R. K.; Ahmed, A. E.; Ansari, Ghulam.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 53, No. 2, 1986, p. 233-236.

Research output: Contribution to journalArticle

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