Influence of nicotine on gastrin and peptide YY in the rat

Guillermo Gomez, Isabel Lambertz, Vidyavathi Udupi, Qi Xiang, James C. Thompson, George H. Greeley

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalRegulatory Peptides
Issue number1
StatePublished - Nov 14 1996
Externally publishedYes


  • Gene expression
  • Gut
  • Northern blotting
  • RIA

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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