Influence of nicotine on gastrin and peptide YY in the rat

Guillermo Gomez; Isabel Lambertz; Vidyavathi Udupi; Qi Xiang; James C. Thompson; George H. Greeley

doi:10.1016/S0167-0115(96)00107-3

Influence of nicotine on gastrin and peptide YY in the rat

Guillermo Gomez, Isabel Lambertz, Vidyavathi Udupi, Qi Xiang, James C. Thompson, George H. Greeley

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.

Original language	English (US)
Pages (from-to)	55-61
Number of pages	7
Journal	Regulatory Peptides
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/S0167-0115(96)00107-3
State	Published - Nov 14 1996
Externally published	Yes

Keywords

Gene expression
Gut
Northern blotting
RIA

ASJC Scopus subject areas

Physiology
Biochemistry
Endocrinology
Clinical Biochemistry
Cellular and Molecular Neuroscience

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10.1016/S0167-0115(96)00107-3

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abstract = "The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.",

keywords = "Gene expression, Gut, Northern blotting, RIA",

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note = "Funding Information: This work was supported by grants from the Smokeless Tobacco Research Council (0423-01) and from the National Institutes of Health (RO1 DK15241 and PO1 DK35608).",

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AU - Gomez, Guillermo

AU - Lambertz, Isabel

AU - Udupi, Vidyavathi

AU - Xiang, Qi

AU - Thompson, James C.

AU - Greeley, George H.

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N2 - The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.

AB - The objective of this study was to examine the effects of nicotine and high-fat diets on gastrin and peptide YY (PYY) homeostasis in the rat. Antral levels of gastrin mRNA and peptide and ileal and colonic levels of PYY mRNA and peptide were examined. Serum levels of gastrin in response to food were also measured. Control rats were ad-lib fed or pair-fed according to the daily food intake of nicotine-treated rats. The results of this study indicate that nicotine treatment and fat diets can influence gastrin and PYY gene expression in the gastrointestinal tract.

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KW - Northern blotting

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Influence of nicotine on gastrin and peptide YY in the rat

Abstract

Keywords

ASJC Scopus subject areas

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