Influence of previous Zika virus infection on acute dengue episode

Cassia F. Estofolete; Alice F. Versiani; Fernanda S. Dourado; Bruno H.G.A. Milhim; Carolina C. Pacca; Gislaine C.D. Silva; Nathalia Zini; Barbara F. Dos Santos; Flora A. Gandolfi; Natalia F.B. Mistrão; Pedro H.C. Garcia; Rodrigo S. Rocha; Lee Gehrke; Irene Bosch; Rafael E. Marques; Mauro M. Teixeira; Flavio G. da Fonseca; Nikos Vasilakis; Maurício L. Nogueira

doi:10.1371/journal.pntd.0011710

Influence of previous Zika virus infection on acute dengue episode

Cassia F. Estofolete, Alice F. Versiani, Fernanda S. Dourado, Bruno H.G.A. Milhim, Carolina C. Pacca, Gislaine C.D. Silva, Nathalia Zini, Barbara F. Dos Santos, Flora A. Gandolfi, Natalia F.B. Mistrão, Pedro H.C. Garcia, Rodrigo S. Rocha, Lee Gehrke, Irene Bosch, Rafael E. Marques, Mauro M. Teixeira, Flavio G. da Fonseca, Nikos Vasilakis, Maurício L. Nogueira

Pathology

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Abstract

Background The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection. Methodology/Principal findings We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue. Conclusions/Significance Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.

Original language	English (US)
Article number	e0011710
Journal	PLoS neglected tropical diseases
Volume	17
Issue number	11 November
DOIs	https://doi.org/10.1371/journal.pntd.0011710
State	Published - Nov 2023

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Infectious Diseases

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Estofolete, C. F., Versiani, A. F., Dourado, F. S., Milhim, B. H. G. A., Pacca, C. C., Silva, G. C. D., Zini, N., Dos Santos, B. F., Gandolfi, F. A., Mistrão, N. F. B., Garcia, P. H. C., Rocha, R. S., Gehrke, L., Bosch, I., Marques, R. E., Teixeira, M. M., da Fonseca, F. G., Vasilakis, N., & Nogueira, M. L. (2023). Influence of previous Zika virus infection on acute dengue episode. PLoS neglected tropical diseases, 17(11 November), Article e0011710. https://doi.org/10.1371/journal.pntd.0011710

Estofolete, CF, Versiani, AF, Dourado, FS, Milhim, BHGA, Pacca, CC, Silva, GCD, Zini, N, Dos Santos, BF, Gandolfi, FA, Mistrão, NFB, Garcia, PHC, Rocha, RS, Gehrke, L, Bosch, I, Marques, RE, Teixeira, MM, da Fonseca, FG, Vasilakis, N & Nogueira, ML 2023, 'Influence of previous Zika virus infection on acute dengue episode', PLoS neglected tropical diseases, vol. 17, no. 11 November, e0011710. https://doi.org/10.1371/journal.pntd.0011710

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abstract = "Background The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection. Methodology/Principal findings We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue. Conclusions/Significance Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.",

author = "Estofolete, {Cassia F.} and Versiani, {Alice F.} and Dourado, {Fernanda S.} and Milhim, {Bruno H.G.A.} and Pacca, {Carolina C.} and Silva, {Gislaine C.D.} and Nathalia Zini and {Dos Santos}, {Barbara F.} and Gandolfi, {Flora A.} and Mistr{\~a}o, {Natalia F.B.} and Garcia, {Pedro H.C.} and Rocha, {Rodrigo S.} and Lee Gehrke and Irene Bosch and Marques, {Rafael E.} and Teixeira, {Mauro M.} and {da Fonseca}, {Flavio G.} and Nikos Vasilakis and Nogueira, {Maur{\'i}cio L.}",

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AU - Milhim, Bruno H.G.A.

AU - Pacca, Carolina C.

AU - Silva, Gislaine C.D.

AU - Zini, Nathalia

AU - Dos Santos, Barbara F.

AU - Gandolfi, Flora A.

AU - Mistrão, Natalia F.B.

AU - Garcia, Pedro H.C.

AU - Rocha, Rodrigo S.

AU - Gehrke, Lee

AU - Bosch, Irene

AU - Marques, Rafael E.

AU - Teixeira, Mauro M.

AU - da Fonseca, Flavio G.

AU - Vasilakis, Nikos

AU - Nogueira, Maurício L.

PY - 2023/11

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AB - Background The co-circulation of flaviviruses in tropical regions has led to the hypothesis that immunity generated by a previous dengue infection could promote severe disease outcomes in subsequent infections by heterologous serotypes. This study investigated the influence of antibodies generated by previous Zika infection on the clinical outcomes of dengue infection. Methodology/Principal findings We enrolled 1,043 laboratory confirmed dengue patients and investigated their prior infection to Zika or dengue. Severe forms of dengue disease were more frequent in patients with previous Zika infection, but not in those previously exposed to dengue. Conclusions/Significance Our findings suggest that previous Zika infection may represent a risk factor for subsequent severe dengue disease, but we did not find evidence of antibody-dependent enhancement (higher viral titer or pro-inflammatory cytokine overexpression) contributing to exacerbation of the subsequent dengue infection.

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Influence of previous Zika virus infection on acute dengue episode

Abstract

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