TY - JOUR
T1 - Influences of nanomaterials on the barrier function of epithelial cells
AU - Ali, Shariq
AU - Rytting, Erik
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2014.
PY - 2014
Y1 - 2014
N2 - Recent advances in nanotechnology have led to exciting opportunities in medicine, energy, manufacturing, and other fields. Nevertheless, it is important to adequately assess the potential impacts of nanomaterial exposure. This chapter focuses on the interactions of nanomaterials with epithelial barriers in the lungs, intestine, kidneys, skin, and placenta. Methods for determining transepithelial electrical resistance and paracellular permeability are described. Effects on cell viability and barrier integrity depend on the chemical nature of the nanomaterial, nanoparticle size, surface coatings, and concentration. Disruption of tight junctions can affect permeability and interfere with normal regulatory processes of the epithelial barrier. Future research is needed to better understand the possibilities and the limits of novel approaches in nanotechnology.
AB - Recent advances in nanotechnology have led to exciting opportunities in medicine, energy, manufacturing, and other fields. Nevertheless, it is important to adequately assess the potential impacts of nanomaterial exposure. This chapter focuses on the interactions of nanomaterials with epithelial barriers in the lungs, intestine, kidneys, skin, and placenta. Methods for determining transepithelial electrical resistance and paracellular permeability are described. Effects on cell viability and barrier integrity depend on the chemical nature of the nanomaterial, nanoparticle size, surface coatings, and concentration. Disruption of tight junctions can affect permeability and interfere with normal regulatory processes of the epithelial barrier. Future research is needed to better understand the possibilities and the limits of novel approaches in nanotechnology.
KW - Cells
KW - Epithelial
KW - Nanomaterials
KW - Nanoparticles
KW - Nanotoxicology
KW - Tight junctions
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U2 - 10.1007/978-94-017-8739-0_3
DO - 10.1007/978-94-017-8739-0_3
M3 - Article
C2 - 24683026
AN - SCOPUS:84904281280
SN - 0065-2598
VL - 811
SP - 45
EP - 54
JO - Advances in experimental medicine and biology
JF - Advances in experimental medicine and biology
ER -