Inherited thrombophilia and stillbirth

George R. Saade, Claire McLintock

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Thrombophilias are inherited or acquired conditions that predispose individuals to thromboembolism. New inherited thrombophilias are recognized each year. Some, but not all, studies have found an association between inherited thrombophilias and adverse pregnancy outcomes, including fetal loss. The controversy regarding the clinical implications of thrombophilias in pregnancy is clouded by differences in study populations, the number of thrombophilias tested, interactions between thrombophilias, and the retrospective nature of most studies, just to name a few factors. The lack of adequately designed studies also extends to clinical management. Clear evidence to determine when to test, whom to test, which thrombophilias to test for, when to treat, and what to treat with is not available. Further studies to investigate these questions are urgently needed.

Original languageEnglish (US)
Pages (from-to)51-69
Number of pages19
JournalSeminars in Perinatology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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