Inhibiting breast cancer progression by exploiting TGFβ signaling

Sarah Baxley, Rosa Serra

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Transforming Growth Factor β (TGFβ) signaling influences most aspects of cellular function in addition to playing a major role in organ development, remodeling, and repair. Given the wide range of effects induced by TGFβ, it is not surprising that alterations in TGFβ signaling have been implicated in development and progression of many different cancer types. Within the context of breast cancer itself, TGFβ is known to have a dual nature, being both tumorsuppressive during early breast cancer development and tumor-promoting during breast cancer metastasis. Targets for breast cancer therapeutics are greatly needed to decrease morbidity and mortality from this devastating disease. Here, we summarize what is known about TGFβ in breast cancer progression and discuss potential TGFβ targets for breast cancer therapeutics.

Original languageEnglish (US)
Pages (from-to)1089-1102
Number of pages14
JournalCurrent Drug Targets
Volume11
Issue number9
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Transforming Growth Factors
Breast Neoplasms
Tumors
Repair
Neoplasm Metastasis
Morbidity
Mortality
Therapeutics
Neoplasms

Keywords

  • Apoptosis
  • Breast cancer
  • Cytostatic
  • Immune regulation
  • Metastasis
  • Stem cell
  • TGFβ

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Inhibiting breast cancer progression by exploiting TGFβ signaling. / Baxley, Sarah; Serra, Rosa.

In: Current Drug Targets, Vol. 11, No. 9, 01.12.2010, p. 1089-1102.

Research output: Contribution to journalArticle

Baxley, Sarah ; Serra, Rosa. / Inhibiting breast cancer progression by exploiting TGFβ signaling. In: Current Drug Targets. 2010 ; Vol. 11, No. 9. pp. 1089-1102.
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