Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock

Csaba Szabo, Andrew L. Salzman

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Potassium channels closed by increases in intracellular ATP levels (KATP channels) have been described in vascular smooth muscle cells and other cell types. These channels are responsive to the metabolic state of the cells, and can be opened by a decrease in intracellular ATP levels and intra- or extracellular acidosis. Hemorrhagic shock is associated with early vasomotor paralysis as well as with early derangements in the intracellular metabolic status. Here we have tested whether activation of KATP channels contributes to the vasodilatation and early mortality in a rat model of severe hemorrhagic shock. In anesthetized rats hemorrhaged to a mean arterial blood pressure (MAP) of 35 mmHg, inhibition of KATP channels with glibenclamide or tolazamide (10 mg/kg i.v. bolus injection followed by an infusion of 10 mg/kg/h for 60 min), rapidly increased MAP and improved survival rate. The same dose of the KATP channel inhibitors did not cause a significant increase of MAP in animals not subjected to hemorrhage. The approach of inhibition of KATP channel activation in hemorrhagic shock is worthy of further investigations to determine whether it may represent a novel approach for early resuscitation during hemorrhage.

Original languageEnglish (US)
Pages (from-to)391-394
Number of pages4
JournalShock
Volume5
Issue number6
StatePublished - Jun 1996
Externally publishedYes

Fingerprint

Hemorrhagic Shock
Potassium Channels
KATP Channels
Arterial Pressure
Adenosine Triphosphate
Tolazamide
Hemorrhage
Glyburide
Acidosis
Vascular Smooth Muscle
Vasodilation
Resuscitation
Paralysis
Smooth Muscle Myocytes
Survival Rate
Injections
Mortality

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Physiology

Cite this

Inhibition of ATP-activated potassium channels exerts pressor effects and improves survival in a rat model of severe hemorrhagic shock. / Szabo, Csaba; Salzman, Andrew L.

In: Shock, Vol. 5, No. 6, 06.1996, p. 391-394.

Research output: Contribution to journalArticle

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