Inhibition of bacterial adherence to rat bladder epithelial cells by human immune serum globulin

Robert C. Fader, Clifford W. Houston, Charles P. Davis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The ability of commerical human immune serum globulin (HISG) to inhibit the adherence of urinary tract infection isolates to rat bladder epithelial cells was investigated utilizing an in vitro adherence system. Significant decreases in adherence were noted when strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae were tested against five HISG preparations. An enzyme-linked immunosorbent assay indicated that all five HISG preparations also contained antibodies against type-1 pili isolated from Klebsiella pneumoniae. The presence of antibodies directed against a bacterial adhesin and the effectiveness of HISG in inhibiting the attachment of a wide range of urinary pathogens to bladder cells suggest that HISG may have practical therapeutic values in the prophylaxis of diseases where bacterial adherence is a prerequisite for the initiation of infection.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalCurrent Microbiology
Issue number1
StatePublished - Jan 1984
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology


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