Inhibition of bacterial adherence to rat bladder epithelial cells by human immune serum globulin

Robert C. Fader, Clifford W. Houston, Charles P. Davis

Research output: Contribution to journalArticle

Abstract

The ability of commerical human immune serum globulin (HISG) to inhibit the adherence of urinary tract infection isolates to rat bladder epithelial cells was investigated utilizing an in vitro adherence system. Significant decreases in adherence were noted when strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Enterobacter cloacae were tested against five HISG preparations. An enzyme-linked immunosorbent assay indicated that all five HISG preparations also contained antibodies against type-1 pili isolated from Klebsiella pneumoniae. The presence of antibodies directed against a bacterial adhesin and the effectiveness of HISG in inhibiting the attachment of a wide range of urinary pathogens to bladder cells suggest that HISG may have practical therapeutic values in the prophylaxis of diseases where bacterial adherence is a prerequisite for the initiation of infection.

Original languageEnglish (US)
Pages (from-to)29-33
Number of pages5
JournalCurrent Microbiology
Volume10
Issue number1
DOIs
StatePublished - Jan 1984

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Serum Globulins
Immunoglobulins
Immune Sera
Urinary Bladder
Epithelial Cells
Klebsiella pneumoniae
Bacterial Adhesins
Enterobacter cloacae
Proteus mirabilis
Antibodies
Urinary Tract Infections
Enzyme-Linked Immunosorbent Assay
Escherichia coli
Infection

ASJC Scopus subject areas

  • Microbiology

Cite this

Inhibition of bacterial adherence to rat bladder epithelial cells by human immune serum globulin. / Fader, Robert C.; Houston, Clifford W.; Davis, Charles P.

In: Current Microbiology, Vol. 10, No. 1, 01.1984, p. 29-33.

Research output: Contribution to journalArticle

Fader, Robert C. ; Houston, Clifford W. ; Davis, Charles P. / Inhibition of bacterial adherence to rat bladder epithelial cells by human immune serum globulin. In: Current Microbiology. 1984 ; Vol. 10, No. 1. pp. 29-33.
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