Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein

Mathieu Iampietro, Annie Gravel, Louis Flamand

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nuclear factor of activated T cell (NFAT) proteins are key regulators involved in multiple physiological mechanisms, such as immune response and cell growth. The capacity of selective calcineurin/NFAT inhibitors to decrease NFAT-dependent cancer cell progression, particularly in breast cancer, has already been demonstrated. In this study, we report a role for the human herpesvirus 6B (HHV-6B) U54 tegument protein in inhibiting MCF-7 breast cancer cell proliferation by inhibiting NFAT activation.

Original languageEnglish (US)
Pages (from-to)12910-12914
Number of pages5
JournalJournal of Virology
Volume88
Issue number21
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

NFATC Transcription Factors
Human Herpesvirus 6
Calcineurin
breast neoplasms
cell proliferation
T-lymphocytes
Cell Proliferation
Breast Neoplasms
Proteins
proteins
cell growth
immune response
neoplasm cells
Growth
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Medicine(all)

Cite this

Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein. / Iampietro, Mathieu; Gravel, Annie; Flamand, Louis.

In: Journal of Virology, Vol. 88, No. 21, 2014, p. 12910-12914.

Research output: Contribution to journalArticle

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