@article{29bbeb73ef5b40e59b25b26ebcf8a227,
title = "Inhibition of innate immune response ameliorates zika virus-induced neurogenesis deficit in human neural stem cells",
abstract = "Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study, we used Asian-American lineage ZIKV strain PRVABC59 to infect primary human NS/PCs originally derived from fetal brains. We found that ZIKV overactivated key molecules in the innate immune pathways to impair neurogenesis in a cell stage-dependent manner. Inhibiting the overactivated innate immune responses amelio-rated ZIKV-induced neurogenesis reduction. This study thus suggests that orchestrating the host innate immune responses in NS/PCs after ZIKV infection could be promising therapeu-tic approach to attenuate ZIKV-associated neuropathology.",
author = "Pei Xu and Junling Gao and Chao Shan and Dunn, {Tiffany J.} and Xuping Xie and Hongjie Xia and Jing Zou and Thames, {Beatriz H.} and Amulya Sajja and Yongjia Yu and Freiberg, {Alexander N.} and Nikos Vasilakis and Shi, {Pei Yong} and Weaver, {Scott C.} and Ping Wu",
note = "Funding Information: This work was supported by NIH grants to P.W. (R21AI129509-01), S.C.W. (AI120942), P-Y.S. (AI142759, AI127744, and AI136126). Other funding sources include UTMB CRO Special Fund (P.W.), the John S. Dunn Foundation (P.W., S.C. W., P-Y.S.), the Kleberg Foundation (P-Y.S.), the Amon G. Carter Foundation (P-Y.S.), the Gilson Longenbaugh Foundation (P-Y.S.), the Summerfield Robert Foundation (P-Y.S.), NIH/ NIAID 5T35 AI078878 (B.H.T. and A.S.), and McLaughlin Fellowship (P. X.). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: : {\textcopyright} 2021 Xu et al.",
year = "2021",
month = mar,
doi = "10.1371/journal.pntd.0009183",
language = "English (US)",
volume = "15",
journal = "PLoS Neglected Tropical Diseases",
issn = "1935-2727",
publisher = "Public Library of Science",
number = "3",
}