Inhibition of N-methyl-d-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration

Lawrence D. Snell, Susan M. Jones, Kenneth M. Johnson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This study examined the ability of phencyclidine (PCP) to inhibit the responses to N-methyl-d-aspartate (NMDA) in depolarizing concentrations of K+. The effects of PCP and Mg2+ on NMDA-induced norepinephrine release from hippocampal slices were measured during superfusion with various extracellular concentrations of K+. The IC50 values for Mg2+ and PCP were significantly higher in K+ concentrations above 6 mM. These data are supportive of the hypothesis that PCP produces a voltage-dependent blockade of NMDA-activated ion channels.

Original languageEnglish (US)
Pages (from-to)333-337
Number of pages5
JournalNeuroscience Letters
Volume78
Issue number3
DOIs
StatePublished - Aug 5 1987

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Phencyclidine
Aspartic Acid
Norepinephrine
Potassium
Ion Channels
Inhibitory Concentration 50

Keywords

  • Hippocampus
  • N-Methyl-d-aspartate
  • Norepinephrine release
  • Phencyclidine
  • Potassium
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Inhibition of N-methyl-d-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration. / Snell, Lawrence D.; Jones, Susan M.; Johnson, Kenneth M.

In: Neuroscience Letters, Vol. 78, No. 3, 05.08.1987, p. 333-337.

Research output: Contribution to journalArticle

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