Inhibition of N-methyl-d-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration

Lawrence D. Snell; Susan M. Jones; Kenneth M. Johnson

doi:10.1016/0304-3940(87)90383-1

Inhibition of N-methyl-d-aspartate-induced hippocampal [³H]norepinephrine release by phencyclidine is dependent on potassium concentration

Lawrence D. Snell, Susan M. Jones, Kenneth M. Johnson

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

This study examined the ability of phencyclidine (PCP) to inhibit the responses to N-methyl-d-aspartate (NMDA) in depolarizing concentrations of K⁺. The effects of PCP and Mg²⁺ on NMDA-induced norepinephrine release from hippocampal slices were measured during superfusion with various extracellular concentrations of K⁺. The IC₅₀ values for Mg²⁺ and PCP were significantly higher in K⁺ concentrations above 6 mM. These data are supportive of the hypothesis that PCP produces a voltage-dependent blockade of NMDA-activated ion channels.

Original language	English (US)
Pages (from-to)	333-337
Number of pages	5
Journal	Neuroscience Letters
Volume	78
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(87)90383-1
State	Published - Aug 5 1987
Externally published	Yes

Keywords

Hippocampus
N-Methyl-d-aspartate
Norepinephrine release
Phencyclidine
Potassium
Rat

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(87)90383-1

Cite this

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title = "Inhibition of N-methyl-d-aspartate-induced hippocampal [3H]norepinephrine release by phencyclidine is dependent on potassium concentration",

abstract = "This study examined the ability of phencyclidine (PCP) to inhibit the responses to N-methyl-d-aspartate (NMDA) in depolarizing concentrations of K+. The effects of PCP and Mg2+ on NMDA-induced norepinephrine release from hippocampal slices were measured during superfusion with various extracellular concentrations of K+. The IC50 values for Mg2+ and PCP were significantly higher in K+ concentrations above 6 mM. These data are supportive of the hypothesis that PCP produces a voltage-dependent blockade of NMDA-activated ion channels.",

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AU - Jones, Susan M.

AU - Johnson, Kenneth M.

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AB - This study examined the ability of phencyclidine (PCP) to inhibit the responses to N-methyl-d-aspartate (NMDA) in depolarizing concentrations of K+. The effects of PCP and Mg2+ on NMDA-induced norepinephrine release from hippocampal slices were measured during superfusion with various extracellular concentrations of K+. The IC50 values for Mg2+ and PCP were significantly higher in K+ concentrations above 6 mM. These data are supportive of the hypothesis that PCP produces a voltage-dependent blockade of NMDA-activated ion channels.

KW - Hippocampus

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KW - Norepinephrine release

KW - Phencyclidine

KW - Potassium

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